Efficacy of danazol treatment for minimal endometriosis in infertile women. A prospective, randomized study.
article
OA: closed
CC0
⤵ 63 in-corpus citations
AI-generated summary
This study found no significant difference in pregnancy rates between infertile women with minimal endometriosis treated with danazol for six months and an untreated control group.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
We compared pregnancy rates between a danazol-treated and an untreated group of infertile women with minimal endometriosis. After completion of a basic infertility workup and laparoscopy, women with minimal endometriosis were entered into the study and randomly selected to receive either a six-month course of danazol or no treatment at all. Those patients with other infertility factors were included in the study only if the factors were correctable and ultimately determined to be noncontributory. Life-table analysis was used to compare pregnancy rates between the two groups over a 12-month period that started immediately after laparoscopy in the untreated group and after completion of danazol therapy in the treated group. The cumulative pregnancy rate (+/- SEM) was 37.2 +/- 8.4% in the danazol group (n = 37) and 57.4 +/- 10.4% in the untreated group (n = 36) (NS, P greater than .10). This prospective, randomized study showed danazol to be ineffective in improving pregnancy rates over doing nothing at all in patients with minimal endometriosis.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
Cited by (50)
- Beyond the surface: Does stage I-II endometriosis impact fertility? Exploring the challenges of mild disease 2024
- Does Gonadotropin-Releasing Hormone Agonist Administration Before Assisted Reproduction Techniques Improve Pregnancy Rates in Women With Endometriosis? 2024
- Ultralong administration of gonadotropin-releasing hormone agonists before in vitro fertilization improves fertilization rate but not clinical pregnancy rate in women with mild endometriosis: a prospective, randomized, controlled trial 2020
- Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment 2019
- Endometriosis and Infertility Management 2018
- Endometriosis 2012
- Endometriosis and infertility: a committee opinion 2012
- Guidelines for management of endometriosis 2011
- Medical Therapy of Endometriosis: Subfertility 2011
- Sterilitätstherapie bei Endometriose 2010
- An overview of non-obstructive etiopathogenic mechanisms of endometriosis-related infertility 2010
- Clinical Aspects of Endometriosis 2010
- Reproductive Surgery for Endometriosis-Associated Infertility 2008
- Ovulation suppression for endometriosis for women with subfertility 2007
- Danazol for pelvic pain associated with endometriosis 2007
- Endometriosis intestinal. Estado actual 2007
- The treatment of mild endometriosis with laser laparoscopy: a two-step treatment analysis of patients whose primary therapy was successful. 2006
- Endometriosis and infertility 2004
- Evidence-based reproductive surgery: endometriosis 2004
- Endometriosis and infertility 2004
- Endometriosis and infertility The Practice Committee of the American Society for Reproductive Medicine 2004
- Ovulation suppression for endometriosis 2003
- Tratamiento de la endometriosis y medicina basada en la evidencia 2003
- Diagnosis and treatment of endometriosis 2003
- Endometriosis 2003
- An evidence-based evaluation of endometriosis-associated infertility 2003
- Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization-embryo transfer in patients with endometriosis 2002
- The Treatment of Endometriosis 2002
- Danazol for pelvic pain associated with endometriosis 2001
- The success of laser laparoscopy in the treatment of endometriosis: a two-step analysis. 2001
- Medical management of endometriosis and infertility 2000
- Minimal/mild endometriosis and infertility 2000
- Today's treatments: medical, surgical and in partnership 1999
- The evidence for the management of endometriosis 1998
- Treatment of infertility associated with endometriosis 1998
- Modern Approach to Endometriosis 1997
- MODERN MEDICAL MANAGEMENT OF ENDOMETRIOSIS 1997
- Prediction of pregnancy in infertile women based on the American Society for Reproductive Medicine's revised classification of endometriosis 1997
- The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro 1996
- Pathogenesis of Infertility in Endometriosis 1995
- Endometriosis: Current Management 1995
- Approach to the Patient With Suspected Endometriosis 1995
- <i>In vitro</i> fertilization/embryo transfer in unexplained infertility and minimal peritoneal endometriosis 1995
- Surgical treatment of endometriosis-associated infertility: Meta-analysis compared with survival analysis 1994
- Diagnosis and investigation of endometriosis 1993
- MANAGEMENT OF ENDOMETRIOSIS IN WOMEN OLDER THAN 40 YEARS OF AGE 1993
- Changing concepts of medical treatment of endometriosis 1993
- 9 Endometriosis: Medical therapy 1993
- The aetiology and pathogenesis of endometriosis 1992
- Efficacy of danazol treatment in infertile patients with endometriosis. 1992
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:09:25.758913+00:00
License: CC0
· commercial use OK