MODERN MEDICAL MANAGEMENT OF ENDOMETRIOSIS

L. Michael Kettel; L M Kettel; William P. Hummel; W P Hummel

doi:10.1016/s0889-8545(05)70309-0

MODERN MEDICAL MANAGEMENT OF ENDOMETRIOSIS

L. Michael Kettel, L M Kettel, William P. Hummel, W P Hummel

Obstetrics and gynecology clinics of North America · 1997 · vol. 24(2) , pp. 361–373 · doi:10.1016/s0889-8545(05)70309-0 · PMID:9163772 · W2156079493

review OA: closed CC0 ⤵ 25 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews the current medical management strategies for endometriosis, focusing on hormonal therapies, pain management, and emerging treatment options.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Danazol Danazol Endometriosis Estrogen Antagonists Estrogen Antagonists Estrogen Replacement Therapy Female Gestrinone Gestrinone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Hormone Antagonists Hormone Antagonists Humans Mifepristone Mifepristone Progesterone Congeners Progesterone Congeners

Citation neighborhood

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References (65)

Administration of Nasal Nafarelin as Compared with Oral Danazol for Endometriosis via openalex
Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: a 1-year primate study via openalex
Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: a 1-year primate study. via openalex
A randomized double-blind prospective trial of two doses of gestrinone in the treatment of endometriosis via openalex
Buserelin acetate versus expectant management in the treatment of infertility associated with minimal or mild endometriosis: A randomized clinical trial via openalex
Clinical Studies with an Antigonadotropin-Danazol via openalex
Combination medical and surgical therapy for infertile patients with endometriosis. via openalex
Combination Medical and Surgical Therapy for Infertile Patients with Endometriosis via openalex
Comparison of different modalities of treatment for minimal and mild endometriosis via openalex
CURRENT STATUS OF THE HORMONAL TREATMENT OF ENDOMETRIOSIS via openalex
Danazol has progestin-like actions on the human endometrium via openalex
Efficacy of danazol treatment for minimal endometriosis in infertile women. A prospective, randomized study. via openalex
Endocrine responses to long-term administration of the antiprogesterone RU486 in patients with pelvic endometriosis via openalex
Endometrial effects of long-term low-dose administration of RU486 via openalex
Endometriosis—Associated Infertility via openalex
Gonadotropin-releasing hormone agonist plus estrogen-progestin “add-back” therapy for endometriosis-related pelvic pain via openalex
Hormone treatment of endometriosis: The estrogenthreshold hypothesis via openalex
Human Endometrium and Endometriotic Tissue Obtained Simultaneously via openalex
Immunohistochemical analysis of estrogen and progesterone receptors in endometriosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy via openalex
Impact of gestrinone on the course of asymptomatic endometriosis. via openalex
Inhibition of folliculogenesis and ovulation by the antiprogesterone RU 486. via openalex
Laparoscopic control of Danazol therapy on pelvic endometriosis via openalex
Nafarelin for endometriosis: a large-scale, danazol-controlled trial of efficacy and safety, with 1-year follow-up via openalex
Nafarelin for endometriosis: A large-scale, danazol-controlled trial of efficacy and safety, with 1-year follow-up via openalex
Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex
Prolonged gonadotropin-releasing hormone agonist treatment of symptomatic endometriosis: the role of cyclic sodium etidronate and low-dose norethindrone “add-back” therapy via openalex
Reduction of vasomotor symptoms and bone mineral density loss with combined norethindrone and long-acting gonadotropin-releasing hormone agonist therapy of symptomatic endometriosis: a prospective randomized trial via openalex
Reduction of vasomotor symptoms and bone mineral density loss with combined norethindrone and long-acting gonadotropin-releasing hormone agonist therapy of symptomatic endometriosis: a prospective randomized trial. via openalex
REVERSIBLE TRABECULAR BONE DENSITY LOSS FOLLOWING INDUCED HYPO‐OESTROGENISM WITH THE GnRH ANALOGUE BUSERELIN IN PREMENOPAUSAL WOMEN via openalex
The effect of RU486 administered during the proliferative and secretory phase of the cycle on the bleeding pattern, hormonal parameters and the endometrium via openalex
The Relation of Endometriosis to Menstrual Characteristics, Smoking, and Exercise via openalex
The Treatment of Endometriosis by Inducing Pseudopregnancy with Ovarian Hormones via openalex
The Unsuspected Pelvic Factor in the Infertility Investigation via openalex
The use of newer progestins in the treatment of endometriosis via openalex
THE USE OF STILBESTROL FOR ENDOMETRIOSIS via openalex
Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist plus medroxyprogesterone acetate. via openalex
Treatment of Endometriosis with Estrogen-Progestin Combination and Progestogens Alone via openalex
Treatment of endometriosis with leuprorelin acetate depot: a German multicentre study. via openalex
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Cited by (25)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-13T22:10:52.568893+00:00

License: CC0 · commercial use OK

[1] Administration of Nasal Nafarelin as Compared with Oral Danazol for Endometriosis via openalex

[2] Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: a 1-year primate study via openalex

[3] Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: a 1-year primate study. via openalex

[4] A randomized double-blind prospective trial of two doses of gestrinone in the treatment of endometriosis via openalex

[5] Buserelin acetate versus expectant management in the treatment of infertility associated with minimal or mild endometriosis: A randomized clinical trial via openalex

[6] Clinical Studies with an Antigonadotropin-Danazol via openalex

[7] Combination medical and surgical therapy for infertile patients with endometriosis. via openalex

[8] Combination Medical and Surgical Therapy for Infertile Patients with Endometriosis via openalex

[9] Comparison of different modalities of treatment for minimal and mild endometriosis via openalex

[10] CURRENT STATUS OF THE HORMONAL TREATMENT OF ENDOMETRIOSIS via openalex

[11] Danazol has progestin-like actions on the human endometrium via openalex

[12] Efficacy of danazol treatment for minimal endometriosis in infertile women. A prospective, randomized study. via openalex

[13] Endocrine responses to long-term administration of the antiprogesterone RU486 in patients with pelvic endometriosis via openalex

[14] Endometrial effects of long-term low-dose administration of RU486 via openalex

[15] Endometriosis—Associated Infertility via openalex

[16] Gonadotropin-releasing hormone agonist plus estrogen-progestin “add-back” therapy for endometriosis-related pelvic pain via openalex

[17] Hormone treatment of endometriosis: The estrogenthreshold hypothesis via openalex

[18] Human Endometrium and Endometriotic Tissue Obtained Simultaneously via openalex

[19] Immunohistochemical analysis of estrogen and progesterone receptors in endometriosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy via openalex

[20] Impact of gestrinone on the course of asymptomatic endometriosis. via openalex

[21] Inhibition of folliculogenesis and ovulation by the antiprogesterone RU 486. via openalex

[22] Laparoscopic control of Danazol therapy on pelvic endometriosis via openalex

[23] Nafarelin for endometriosis: a large-scale, danazol-controlled trial of efficacy and safety, with 1-year follow-up via openalex

[24] Nafarelin for endometriosis: A large-scale, danazol-controlled trial of efficacy and safety, with 1-year follow-up via openalex

[25] Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex

[26] Prolonged gonadotropin-releasing hormone agonist treatment of symptomatic endometriosis: the role of cyclic sodium etidronate and low-dose norethindrone “add-back” therapy via openalex

[27] Reduction of vasomotor symptoms and bone mineral density loss with combined norethindrone and long-acting gonadotropin-releasing hormone agonist therapy of symptomatic endometriosis: a prospective randomized trial via openalex

[28] Reduction of vasomotor symptoms and bone mineral density loss with combined norethindrone and long-acting gonadotropin-releasing hormone agonist therapy of symptomatic endometriosis: a prospective randomized trial. via openalex

[29] REVERSIBLE TRABECULAR BONE DENSITY LOSS FOLLOWING INDUCED HYPO‐OESTROGENISM WITH THE GnRH ANALOGUE BUSERELIN IN PREMENOPAUSAL WOMEN via openalex

[30] The effect of RU486 administered during the proliferative and secretory phase of the cycle on the bleeding pattern, hormonal parameters and the endometrium via openalex

[31] The Relation of Endometriosis to Menstrual Characteristics, Smoking, and Exercise via openalex

[32] The Treatment of Endometriosis by Inducing Pseudopregnancy with Ovarian Hormones via openalex

[33] The Unsuspected Pelvic Factor in the Infertility Investigation via openalex

[34] The use of newer progestins in the treatment of endometriosis via openalex

[35] THE USE OF STILBESTROL FOR ENDOMETRIOSIS via openalex

[36] Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist plus medroxyprogesterone acetate. via openalex

[37] Treatment of Endometriosis with Estrogen-Progestin Combination and Progestogens Alone via openalex

[38] Treatment of endometriosis with leuprorelin acetate depot: a German multicentre study. via openalex

[39] W2062684697 via openalex

[40] W2040929385 via openalex

[41] W2394707818 via openalex

[42] W2039774379 via openalex

[43] W2403465350 via openalex

[44] W2403905984 via openalex

[45] W2407038112 via openalex

[46] W2031495520 via openalex

[47] W2412454843 via openalex

[48] W66902808 via openalex

[49] W2417044776 via openalex

[50] W1975486822 via openalex

[51] W2616608952 via openalex

[52] W1974272316 via openalex

[53] W4252952645 via openalex

[54] W1910306760 via openalex

[55] W1531102169 via openalex

[56] W4296792067 via openalex

[57] W125973494 via openalex

[58] W4300095172 via openalex

[59] W6648090751 via openalex

[60] W6717624033 via openalex

[61] W6717626104 via openalex

[62] W2169039008 via openalex

[63] W6845012053 via openalex

[64] W2150538385 via openalex

[65] W2108976724 via openalex