Efficacy of Every-Other-Day Administration of Conjugated Equine Estrogen and Medroxyprogesterone Acetate on Gonadotropin-Releasing Hormone Agonists Treatment in Women with Endometriosis

M Irahara, Hirokazu Uemura, H Uemura, Toshiyuki Yasui, T Yasui, H Kinoshita, Hiromi Kinoshita, Masayo Yamada, M Yamada, M Tezuka, Michiko Tezuka, Machiko Kiyokawa, M Kiyokawa, M Kamada, Masaharu Kamada, T Aono, Toshihiro Aono
Gynecologic and obstetric investigation · 2001 · vol. 52(4) , pp. 217–222 · doi:10.1159/000052978 · PMID:11729332 · W2043863194
article OA: closed CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found that adding conjugated equine estrogen and medroxyprogesterone acetate every other day to GnRH agonist treatment reduced symptom scores and prevented bone loss in women with endometriosis.

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Abstract

We performed a randomized controlled study to determine the efficacy of add-backed therapy by every-other-day administration of 0.625 mg conjugated equine estrogen (CEE) and 2.5 mg medroxyprogesterone acetate (MPA) on GnRH agonists (GnRH-a) treatment in Japanese women with symptomatic endometriosis. At the end of treatment, serum estrone and estradiol levels in the add-back group (n = 11) were significantly higher than those in the control group (n = 10). The assessment of Beecham classification by bimanual examination, serum CA-125 levels, and the frequency of genital bleeding revealed no significant differences between the two groups. The add-back group showed reduced Kupperman indices relative to those of the control group, and could prevent the loss of bone density. These findings led to a conclusion that GnRH-a therapy added back by every-other-day administration of 0.625 mg CEE and 2.5 mg MPA was a safe and effective treatment for Japanese women with endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Estrogens, Conjugated (USP) Gonadotropin-Releasing Hormone Medroxyprogesterone Acetate Adult Animals Bone Density Bone Remodeling CA-125 Antigen CA-125 Antigen Endometriosis Estradiol Estradiol Estrogens, Conjugated (USP) Estrone Estrone Female Gonadotropin-Releasing Hormone Horses Humans

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References (20)

Cited by (11)

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