Tratamiento de la endometriosis I y II. Revisión de la literatura

In: Revista Colombiana de Obstetricia y Ginecología · 2008 · vol. 59(3) , pp. 223–230 · doi:10.18597/rcog.407 · W1491473470
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This review of literature on endometriosis stages I and II found medical and surgical treatments effective for pain, but surgery appears beneficial for infertility while medical treatments do not.

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This paper is a literature review on treatment of endometriosis stages I and II, focused on managing pain, infertility, and as an adjunct to assisted reproduction techniques, using PubMed/Medline guidance studies from 1992 to 2007. The authors report that for pain in endometriosis I/II, both medical and surgical management are effective, with no clear differences among medical options; treatment selection is said to depend on age, fertility goals, and side effects. For infertility associated with endometriosis, medical therapy is described as not effective, while surgical management appears beneficial by eliminating disease foci, with the caveat that the review emphasizes the need for more randomized controlled trials, including comparisons to placebo or no treatment. This paper is centrally about endometriosis — specifically reviewing treatment options for endometriosis stages I and II across pain, infertility, and reproductive assistance.

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Abstract

Objetivo: el objetivo de este manuscrito es hacer una revisión de la literatura disponible que aborde el tratamiento de la endometriosis I y II para el manejo del dolor, de la infertilidad y como coadyuvante en las técnicas de reproducción asistida.Metodología: se realizó una revisión de la literatura disponible en las bases de datos PubMed/Medline con énfasis en guías de manejo desde 1992 hasta 2007.Resultados: en el tratamiento del dolor en endometriosis I y II, tanto el manejo médico como quirúrgico es efectivo. No hay diferencia entre los diversos tratamientos médicos en la disminución del dolor; su elección estará determinada por la edad, el deseo de fertilidad de la paciente y los efectos secundarios de los mismos. Para el tratamiento de la infertilidad asociada a endometriosis, el tratamiento médico no es efectivo, pero el manejo quirúrgico parece benéfico para los estadios I y II, eliminando los focos de la enfermedad.Conclusión: se requieren más estudios aleatorios controlados, comparando su uso con placebo o sin tratamiento. La cirugía también ha demostrado mejoría, pero no existen estudios que comparen el manejo médico con el quirúrgico.
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Tratamiento de la endometriosis I y II. Revisión de la literatura DOI: https://doi.org/10.18597/rcog.407Palabras clave: endometriosis leve, endometriosis mínima, tratamiento quirúrgico, tratamiento médicoResumen Objetivo: el objetivo de este manuscrito es hacer una revisión de la literatura disponible que aborde el tratamiento de la endometriosis I y II para el manejo del dolor, de la infertilidad y como coadyuvante en las técnicas de reproducción asistida. Metodología: se realizó una revisión de la literatura disponible en las bases de datos PubMed/Medline con énfasis en guías de manejo desde 1992 hasta 2007. Resultados: en el tratamiento del dolor en endometriosis I y II, tanto el manejo médico como quirúrgico es efectivo. No hay diferencia entre los diversos tratamientos médicos en la disminución del dolor; su elección estará determinada por la edad, el deseo de fertilidad de la paciente y los efectos secundarios de los mismos. Para el tratamiento de la infertilidad asociada a endometriosis, el tratamiento médico no es efectivo, pero el manejo quirúrgico parece benéfico para los estadios I y II, eliminando los focos de la enfermedad. Conclusión: se requieren más estudios aleatorios controlados, comparando su uso con placebo o sin tratamiento. La cirugía también ha demostrado mejoría, pero no existen estudios que comparen el manejo médico con el quirúrgico. Biografía del autor/a Ivonne Jeannette Díaz-Yamal Alef Tsade Sanabria-Gaitán Referencias bibliográficas Olive D, Pritts E. Treatment of endometriosis. N Engl J Med 2001;345:266-75. Viganò P, Parazzini F, Somigliana E, Vercellini P. Endometriosis: epidemiology and etiological factors. Best Pract Res Clin Obstet Gynaecol 2004;18:177-200. Sampson JA. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissues into the peritoneal cavity. Am J Obstet Gynecol 1927;14:422-69. Ajossa S, Mais V, Guerriero S, Paoletti AM, Caffiero A. The prevalence of endometriosis in premenopausal women undergoing gynecological surgery. Clin Exp Obstet Gynecol 1994;21:195-7. Burns WN, Schenken RS. Pathophysiology of endometriosis-associated infertility. Clin Obstet Gynecol 1999;42:586-610. D’Hooghe TM, Debrock S, Hill JA, Meuleman C. Endometriosis and subfertility: is the relationship resolved? Semin Reprod Med 2003;21:243-54. Chapron C, Fauconnier A, Vieira M, Barakat H, Dousset B, Pansini V, et al. Anatomical distribution of deeply infiltrating endometriosis: surgical implications and proposition for a classification. Hum Reprod 2003;18:157-61. The Practice Committee of the American Society for Reproductive Medicine. Treatment of pelvic pain associated with Endometriosis. Fertil Steril 2006;86: S18-27. Fedele L, Bianchi S, Di Nola G, Candiani M, Busacca M, Vignali M. The recurrence of endometriosis. Ann N Y Acad Sci 1994;734:358-64. Marjoribanks J, Proctor ML, Farquar C. Fármacos antiinflamatorios no esteroideos para la dismenorrea primaria. (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, número 4, 2007. Oxford: Update Software Ltd. Allen C, Hopewell S, Prentice A.Non-steroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Systematic Rev 2005;(4):CD004753. Vercellini P, Trespidi L, Colombo A, Vendola N, Marchini M, Crosignani PG. A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis. Fertil Steril 1993;60:75-9. Davis L, Kennedy SS, Moore J, Prentice A. Modern combined oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev 2007;(3): CD001019. Selak V, Farquhar C, Prentice A, Singla A. Danazol for pelvic pain associated with endometriosis. Cochrane Database Syst Rev 2007;(4):CD000068. Prentice A, Deary AJ, Bland E. Progestagens and anti-progestagens for pain associated with endometriosis. 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Efficacy of every-other-day administration of conjugated equine estrogen and medroxyprogesterone acetate on gonadotrophin-releasing hormone agonists treatment in women with endometriosis. Gynecol Obstet Invest 2001;52:217-22. Sagsveen M, Farmer JE, Prentice A, Breeze A. Gonadotrophin-releasing hormone analogues for endometriosis: bone mineral density. Cochrane Database Syst Rev 2003;(4):CD001297. Ámsterdam L, Gentry W, Jobanputra S, Wolf M, Rubin JD, Bulun SE. Anastrazole and oral contraceptives: a novel treatment for endometriosis. Fertil Steril 2005;84:300-4. Crosignani PG, Vercellini P, Biffignandi F, Constantini W, Cortesi I, Imparato E. Laparoscopy versus laparotomy in conservative surgical treatment for severe endometriosis. Fertil Steril 1996;66:706-11. SuttonCJG, Ewen SP, Whitelaw N, Haines P. Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis. 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Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis: a controlled randomized study. Fertil Steril 1992;58:28-31. Nulsen JC, Walsh S, Dumez S, Metzger DA. A randomized and longitudinal study of human menopausal gonadotropin with intrauterine insemination in the treatment of infertility. Obstet Gynecol 1993;82:780-6. Barnhart K, Dunsmoor-su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertil Steril 2002;77:1148-55. Sallam HN, García-Velasco JA, Dias S, Arici A, Sallam HN. Long term pituitary down-regulation before in Vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev 2006;(1):CD004635. Yap C, Furness S, Farquhar C. Pre and post operative medical therapy for endometriosis surgery. Cochrane Database Syst Rev 2004;(3):CD003678. 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