Changes in bone mineral content following hormone treatment for endometriosis

M Fukushima
International Journal of Gynecology & Obstetrics · 1995 · vol. 50(S1) , pp. S17–22 · doi:10.1016/0020-7292(95)02510-j · PMID:8529770 · W1979552451
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

Buserelin treatment for endometriosis significantly decreased lumbar vertebral bone mineral content, while danazol treatment resulted in a slight gain despite estrogen reduction.

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Abstract

The effects of danazol and buserelin on the bone mineral content (BMC) of 19 Japanese women with endometriosis were studied. Subjects received 24-week courses of oral danazol (400 mg/day) or intranasal buserelin (900 micrograms/day). Trabecular BMC of the 3rd lumbar vertebra (L3) was monitored by computerized tomography scans pretreatment, at the end of treatment and 6 months post-treatment. In the buserelin group there was a significant decrease in BMC (10-25.4%, P < 0.01) which was not fully reversed 6 months after therapy, and increased parameters of bone resorption. In the danazol group, there was a slight gain in BMC despite a decrease in serum estrogen. Danazol and buserelin have similar success in the treatment of endometriosis, but the decrease in BMC at L3 suggests that cumulative bone loss may follow repeated buserelin therapy.

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Condition tags

endometriosis

MeSH descriptors

Bone Density Buserelin Danazol Endometriosis Adult Alkaline Phosphatase Alkaline Phosphatase Bone Density Bone Density Buserelin Buserelin Creatinine Creatinine Danazol Danazol Endometriosis Endometriosis Endometriosis Estradiol Estradiol

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (16)

Cited by (9)

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