Danazol Suppresses the Production of Interleukin‐1β and Tumor Necrosis Factor by Human Monocytes

Mori H, H Mori, Hidehiro Mori, Nakagawa M, M Nakagawa, Naoki Itoh, N Itoh, Itoh N, K Wada, KEISUKE WADA, Wada K, Teruhiko Tamaya, T Tamaya, Tamaya T
American journal of reproductive immunology (New York, N.Y. : 1989) · 1990 · vol. 24(2) , pp. 45–50 · doi:10.1111/j.1600-0897.1990.tb01037.x · PMID:2288648 · W1973553356
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Danazol dose-dependently suppressed interleukin-1β and tumor necrosis factor production by human monocytes, while estradiol and progesterone only enhanced it in some donors.

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Abstract

ABSTRACT: The effects of estradiol (E 2 ), progesterone (P), and danazol on the production of interleukin‐1β (IL‐1β) and tumor necrosis factor (TNF) by OK‐432 (a streptococcal preparation)‐stimulated monocytes were examined. E 2 and P at physiologic concentrations enhanced IL‐1β and TNF production by monocytes from donors with lower control levels (without steroids added) of IL‐1β and TNF. However, E 2 and P at physiologic concentrations did not affect IL‐1β and TNF production by monocytes from donors with higher control levels of IL‐1β and TNF. Danazol inhibited IL‐1β and TNF production by monocytes in a dose‐dependent manner from not only donors with lower control levels of IL‐1β and TNF but also donors with higher control levels of IL‐1β and TNF. Danazol at a concentration of 10 −6 M significantly suppressed IL‐1β and TNF production in the presence of E 2 and/or P at concentrations giving peak responses of IL‐1β production. These findings suggest possible new mechanisms of action for danazol in the treatment of endometriosis and infertility associated with immune abnormalities.

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Condition tags

endometriosisinfertility

MeSH descriptors

Danazol Interleukin-1 Monocytes Tumor Necrosis Factor-alpha Adult Danazol Estradiol Estradiol Female Humans Interleukin-1 In Vitro Techniques Lymphocyte Activation Lymphocyte Activation Male Monocytes Monocytes Picibanil Picibanil Progesterone

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