Oxidative Stress and its Role in Endometriosis—Mechanistic and Therapeutic Implications

Ashok Agarwal; Sajal Gupta; Rathna Shenoy; Joelle Safi; Aarti Gaglani

doi:10.5005/jp/books/11630_37

Oxidative Stress and its Role in Endometriosis—Mechanistic and Therapeutic Implications

Ashok Agarwal, Sajal Gupta, Rathna Shenoy, Joelle Safi, Aarti Gaglani

In: Clinical Infertility and In Vitro Fertilization · 2012 · pp. 316 · doi:10.5005/jp/books/11630_37 · W2490602474

book-chapter OA: closed CC0 ⤵ 1 in-corpus citation

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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This paper investigates the role of oxidative stress in endometriosis, exploring its underlying mechanisms and potential therapeutic strategies.

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endometriosis

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References (74)

ACOG issues recommendations for the management of endometriosis. American College of Obstetricians and Gynecologists. via openalex
Adhesion of shed menstrual tissue in an in-vitro model using amnion and peritoneum: a light and electron microscopic study via openalex
Altered interleukin-6 production by peritoneal leukocytes from patients with endometriosis via openalex
An evidence-based evaluation of endometriosis-associated infertility via openalex
<b>Ovarian atypical endometriosis: its close association with malignant epithelial tumours</b> via openalex
Cancer risk after a hospital discharge diagnosis of endometriosis via openalex
Clinicopathologic features of ovarian cancer in patients with ovarian endometrioma via openalex
Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial via openalex
Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis via openalex
Danazol Suppresses the Production of Interleukin‐1β and Tumor Necrosis Factor by Human Monocytes via openalex
De novo formation of adhesions in endometriosis: the role of iron and free radical reactions via openalex
Detection of aromatase cytochrome P-450 in endometrial biopsy specimens as a diagnostic test for endometriosis via openalex
Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis via openalex
Endometriosis and ovarian cancer: Thoughts on shared pathophysiology via openalex
Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons via openalex
Enhancement of Human Monocyte and Peritoneal Macrophage Chemiluminescence Activities in Women With Endometriosis via openalex
Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture via openalex
Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26 via openalex
GnRH agonist-suppressed expression of nitric oxide synthases and generation of peroxynitrite in adenomyosis via openalex
Human chorionic gonadotrophin attenuates NF-κB activation and cytokine expression of endometriotic stromal cells via openalex
Increased activation of nuclear factor-kappa B (NF-κB) in isolated peritoneal macrophages of patients with endometriosis via openalex
Increased interleukin-6 levels in peritoneal fluid of infertile patients with active endometriosis via openalex
Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility via openalex
Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1 via openalex
Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin via openalex
Iron overload enhances epithelial cell proliferation in endometriotic lesions induced in a murine model via openalex
Iron overload in the peritoneal cavity of women with pelvic endometriosis via openalex
Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid via openalex
Laparoscopic surgery for large benign ovarian cysts via openalex
Measurable serum markers of oxidative stress response in women with endometriosis via openalex
Mechanistic and Therapeutic Implications of Angiogenesis in Endometriosis via openalex
Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis via openalex
Oxidative stress and peritoneal endometriosis via openalex
Oxidative stress may be a piece in the endometriosis puzzle via openalex
Pentoxifylline After Conservative Surgery for Endometriosis: A Randomized, Controlled Trial via openalex
Peritoneal fluid environment in endometriosis via openalex
Possible Role of Ovarian Epithelial Inflammation in Ovarian Cancer via openalex
Potential involvement of hemoglobin and heme in the pathogenesis of peritoneal endometriosis via openalex
Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial via openalex
Role of cytokines in pathogenesis of endometriosis. via openalex
Role of oxidative stress in endometriosis via openalex
Serum and peritoneal abnormalities in endometriosis: potential use as diagnostic markers. via openalex
Serum interleukin-8 levels are elevated in patients with ovarian endometrioma via openalex
The relationship of endometriosis and ovarian malignancy: a review via openalex
Tumor Necrosis Factor-α-Induced Interleukin-8 (IL-8) Expression in Endometriotic Stromal Cells, Probably through Nuclear Factor-κB Activation: Gonadotropin-Releasing Hormone Agonist Treatment Reduced IL-8 Expression via openalex
Tumor necrosis factor-α induced the release of interleukin-6 from endometriotic stromal cells by the nuclear factor-κB and mitogen-activated protein kinase pathways via openalex
Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet via openalex
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Cited by (1)

The Role of Oxidative Stress in Endometriosis 2015

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[1] ACOG issues recommendations for the management of endometriosis. American College of Obstetricians and Gynecologists. via openalex

[2] Adhesion of shed menstrual tissue in an in-vitro model using amnion and peritoneum: a light and electron microscopic study via openalex

[3] Altered interleukin-6 production by peritoneal leukocytes from patients with endometriosis via openalex

[4] An evidence-based evaluation of endometriosis-associated infertility via openalex

[5] <b>Ovarian atypical endometriosis: its close association with malignant epithelial tumours</b> via openalex

[6] Cancer risk after a hospital discharge diagnosis of endometriosis via openalex

[7] Clinicopathologic features of ovarian cancer in patients with ovarian endometrioma via openalex

[8] Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial via openalex

[9] Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis via openalex

[10] Danazol Suppresses the Production of Interleukin‐1β and Tumor Necrosis Factor by Human Monocytes via openalex

[11] De novo formation of adhesions in endometriosis: the role of iron and free radical reactions via openalex

[12] Detection of aromatase cytochrome P-450 in endometrial biopsy specimens as a diagnostic test for endometriosis via openalex

[13] Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis via openalex

[14] Endometriosis and ovarian cancer: Thoughts on shared pathophysiology via openalex

[15] Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons via openalex

[16] Enhancement of Human Monocyte and Peritoneal Macrophage Chemiluminescence Activities in Women With Endometriosis via openalex

[17] Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture via openalex

[18] Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26 via openalex

[19] GnRH agonist-suppressed expression of nitric oxide synthases and generation of peroxynitrite in adenomyosis via openalex

[20] Human chorionic gonadotrophin attenuates NF-κB activation and cytokine expression of endometriotic stromal cells via openalex

[21] Increased activation of nuclear factor-kappa B (NF-κB) in isolated peritoneal macrophages of patients with endometriosis via openalex

[22] Increased interleukin-6 levels in peritoneal fluid of infertile patients with active endometriosis via openalex

[23] Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility via openalex

[24] Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1 via openalex

[25] Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin via openalex

[26] Iron overload enhances epithelial cell proliferation in endometriotic lesions induced in a murine model via openalex

[27] Iron overload in the peritoneal cavity of women with pelvic endometriosis via openalex

[28] Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid via openalex

[29] Laparoscopic surgery for large benign ovarian cysts via openalex

[30] Measurable serum markers of oxidative stress response in women with endometriosis via openalex

[31] Mechanistic and Therapeutic Implications of Angiogenesis in Endometriosis via openalex

[32] Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis via openalex

[33] Oxidative stress and peritoneal endometriosis via openalex

[34] Oxidative stress may be a piece in the endometriosis puzzle via openalex

[35] Pentoxifylline After Conservative Surgery for Endometriosis: A Randomized, Controlled Trial via openalex

[36] Peritoneal fluid environment in endometriosis via openalex

[37] Possible Role of Ovarian Epithelial Inflammation in Ovarian Cancer via openalex

[38] Potential involvement of hemoglobin and heme in the pathogenesis of peritoneal endometriosis via openalex

[39] Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial via openalex

[40] Role of cytokines in pathogenesis of endometriosis. via openalex

[41] Role of oxidative stress in endometriosis via openalex

[42] Serum and peritoneal abnormalities in endometriosis: potential use as diagnostic markers. via openalex

[43] Serum interleukin-8 levels are elevated in patients with ovarian endometrioma via openalex

[44] The relationship of endometriosis and ovarian malignancy: a review via openalex

[45] Tumor Necrosis Factor-α-Induced Interleukin-8 (IL-8) Expression in Endometriotic Stromal Cells, Probably through Nuclear Factor-κB Activation: Gonadotropin-Releasing Hormone Agonist Treatment Reduced IL-8 Expression via openalex

[46] Tumor necrosis factor-α induced the release of interleukin-6 from endometriotic stromal cells by the nuclear factor-κB and mitogen-activated protein kinase pathways via openalex

[47] Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet via openalex

[48] W2041767365 via openalex

[49] W2035458748 via openalex

[50] W2033705087 via openalex

[51] W2010793153 via openalex

[52] W2007415847 via openalex

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[54] W2145530136 via openalex

[55] W2148700883 via openalex

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