Role of cytokines in pathogenesis of endometriosis.
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This review summarizes current knowledge on how various cytokines contribute to the development of endometriosis by affecting immune surveillance and ectopic endometrial cell implantation and proliferation.
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Abstract
Sampson's theory stating that endometrial cells and fragments desquamate during the menstrual period are transported through Fallopian tubes into the peritoneal cavity where they implant, proliferate and develop into endometriotic lesions is generally accepted [1]. Accumulating data suggest that deficient immunity against retrograde endometrium during menstruation may be involved in the pathophysiology of endometriosis. Recent studies in women with endometriosis have demonstrated functional changes in several immunologic components in the peritoneal fluid as well as in sera of those patients. It was shown, for instance, that a wide pattern of cytokines are involved during endometrial cells implantation, proliferation and forming of endometriotic lesions. Those factors play a critical role in decreased immunologic surveillance, recognition and destruction of ectopic endometrial cells and possible facilitation of the implantation of ectopic endometrial tissues. The present review summarises the current knowledge on the role of different cytokines in the pathophysiology of endometriosis.
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Cited by (37)
- Modulation of the Proliferative Pathway, Neuroinflammation and Pain in Endometriosis 2023
- Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis 2022
- A mouse model of endometriosis that displays vaginal, colon, cutaneous, and bladder sensory comorbidities 2021
- Identification of Serum Biomarkers for Diagnosis of Endometriosis Using Multiplex Immunoassays 2020
- Different Expression Pattern of TIM-3 and Galectin-9 Molecules by Peripheral and Peritoneal Lymphocytes in Women with and without Endometriosis 2020
- Current biomarkers for the detection of endometriosis 2020
- New biomarkers in endometriosis 2019
- Pathogenesis of endometriosis: the genetic/epigenetic theory 2018
- The <scp>CCL</scp>17‐<scp>CCR</scp>4 axis between endometrial stromal cells and macrophages contributes to the high levels of <scp>IL</scp>‐6 in ectopic milieu 2017
- Biomarkers in endometriosis: challenges and opportunities 2017
- Fractalkine/<scp>CX</scp>3<scp>CR</scp>1 is involved in the pathogenesis of endometriosis by regulating endometrial stromal cell proliferation and invasion 2016
- Oxidation-sensitive nociception involved in endometriosis-associated pain 2015
- The Role of Oxidative Stress in Endometriosis 2015
- Expression of Natural Cytotoxicity Receptors on Peritoneal Fluid Natural Killer Cell and Cytokine Production by Peritoneal Fluid Natural Killer Cell in Women with Endometriosis 2014
- Serum Level of IL-10 Is Increased in Patients with Endometriosis, and IL-10 Promotes the Growth of Lesions in a Murine Model 2013
- Oxidative Stress and its Role in Endometriosis—Mechanistic and Therapeutic Implications 2012
- Endometriosis, a modern syndrome. 2011
- Endometriosis: ways of the decision of a problem to the XXI century 2011
- Evaluation of polymorphisms in predicted target sites for micro RNAs differentially expressed in endometriosis 2010
- Avaliação do percentual de células Natural Killer e de auto-anticorpos em sangue periférico de pacientes com endometriose pélvica 2010
- Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet 2009
- Is aromatase expression in the endometrium the cause of endometriosis and related infertility? 2009
- Differential interleukin-6 messenger ribonucleic acid expression and its distribution pattern in eutopic and ectopic endometrium 2008
- Cytokine and immune cell levels in peritoneal fluid and peripheral blood of women with early- and late-staged endometriosis 2008
- Involvement of nuclear factor-κB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin-1β in ectopic endometrial cells 2008
- Avaliação das dosagens das interleucinas 12 e 18 no sangue e no fluido peritoneal de pacientes com endometriose pélvica 2007
- Immunological Aspects of Endometriosis 2007
- Laser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis 2007
- Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample 2007
- Role of oxidative stress in endometriosis 2006
- Decreased peritoneal concentrations of interleukin-15 in women with advanced stage endometriosis 2006
- Analysis of the involvement of CCR5- 32 and CCR2-V64I variants in the development of endometriosis 2004
- Reduction of apoptosis and proliferation in endometriosis 2004
- Adhesion of endometrial cells labeled with 111Indium-tropolonate to peritoneum: a novel in vitro model to study endometriosis 2003
- Evaluation of germline sequence variants within the promoter region of RANTES gene in a cohort of women with endometriosis from Spain 2003
- Increased expression of IgE‐dependent histamine‐releasing factor in endometriotic implants 2003
- Growth factors and cytokines in the reproductive tract of women 1997
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