Expression of Natural Cytotoxicity Receptors on Peritoneal Fluid Natural Killer Cell and Cytokine Production by Peritoneal Fluid Natural Killer Cell in Women with Endometriosis

Ayano Funamizu, Funamizu A, Fukui A, Atsushi Fukui, Kamoi M, Mai Kamoi, Fuchinoue K, Kohei Fuchinoue, Megumi Yokota, Yokota M, Fukuhara R, Rie Fukuhara, Hideki Mizunuma, Mizunuma H
American journal of reproductive immunology (New York, N.Y. : 1989) · 2014 · vol. 71(4) , pp. 359–367 · doi:10.1111/aji.12206 · PMID:24495049 · W2099404743
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Peritoneal fluid NK cells from women with severe endometriosis showed lower NKp46 expression but higher TNF-α and IFN-γ production compared to controls.

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This thesis studied expression of natural cytotoxicity receptors on NK cells and NK-associated cytokine production in women with endometriosis by analyzing peritoneal fluid NK cells at the population level. The key findings reported were that peritoneal fluid NK cells in endometriosis exhibit changes in natural cytotoxicity receptor expression alongside cytokine production profiles. A major caveat is that, as a thesis based on peritoneal fluid samples, the work reflects local peritoneal immune activity and the findings may not directly generalize to other compartments or to endometriosis disease stage. This paper is centrally about endometriosis — it focuses on natural cytotoxicity receptor expression and cytokine production by peritoneal fluid NK cells in women with endometriosis.

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Abstract

PROBLEM: To investigate the relationship between the expression of natural cytotoxicity receptors (NCRs) on peritoneal fluid (PF) natural killer (NK) (pfNK) cells and cytokine production by pfNK cells in women with endometriosis. METHOD OF STUDY: Peritoneal fluid was collected from women with endometriosis undergoing laparoscopic surgery (n = 21) and controls without endometriosis (n = 28). The expression of NK cell surface antigens such as CD16 and NCRs (NKp46, NKp44 and NKp30) on pfNK cells, and cytokines production by pfNK cells [tumor necrosis factor (TNF)-α, IFN-γ, IL-4, IL-10, GM-CSF and transforming growth factor (TGF)-β1] were measured using multicolor flow cytometry. RESULTS: The percentages of CD56(+)/NKp46(+) cells and CD56(dim) /NKp46(+) cells in severe endometriosis group were significantly lower than that in controls. TNF-α and IFN-γ production by pfNK cells in severe endometriosis group was significantly higher than those in controls. CONCLUSION: The differential expression of NKp46, TNF-α, and IFN-γ on pfNK cells in women with severe endometriosis may allow the proliferation and angiogenesis of endometriotic cells.
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WEKO3 アイテム Expression of Natural Cytotoxicity Receptors on Peritoneal Fluid Natural Killer Cell and Cytokine Production by Peritoneal Fluid Natural Killer Cell in Women with Endometriosis http://hdl.handle.net/10129/5367 http://hdl.handle.net/10129/5367b0989e9b-17de-4190-9470-b35434e86f05 | 名前 / ファイル | ライセンス | アクション | |---|---|---| | 本文 (643.0 kB) | | | | 本文要約 (241.1 kB) | | | | 審査要旨 (141.8 kB) | | | | 内容要旨 (296.1 kB) | | | アイテムタイプ | 学位論文 / Thesis or Dissertation(1) | ||||||| |---|---|---|---|---|---|---|---|---| | 公開日 | 2014-06-18 | ||||||| | タイトル | |||||||| | タイトル | Expression of Natural Cytotoxicity Receptors on Peritoneal Fluid Natural Killer Cell and Cytokine Production by Peritoneal Fluid Natural Killer Cell in Women with Endometriosis | ||||||| | 言語 | |||||||| | 言語 | eng | ||||||| | 資源タイプ | |||||||| | 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | ||||||| | 資源タイプ | doctoral thesis | ||||||| | アクセス権 | |||||||| | アクセス権 | open access | ||||||| | アクセス権URI | http://purl.org/coar/access_right/c_abf2 | ||||||| | 著者 | Funamizu, Ayano × Funamizu, Ayano | ||||||| | 著者(ヨミ) | |||||||| | 識別子Scheme | WEKO | ||||||| | 識別子 | 15582 | ||||||| | 姓名 | フナミズ, アヤノ | ||||||| | 著者別名 | |||||||| | 識別子Scheme | WEKO | ||||||| | 識別子 | 15583 | ||||||| | 姓名 | 船水, 文乃 | ||||||| | 著者所属 | |||||||| | 値 | 弘前大学大学院医学研究科 | ||||||| | 内容記述 | |||||||| | 内容記述タイプ | Other | ||||||| | 内容記述 | http://onlinelibrary.wiley.com/doi/10.1111/aji.12206/abstract | ||||||| | 引用 | |||||||| | 内容記述タイプ | Other | ||||||| | 内容記述 | American Journal of Reproductive Immunology, 71(4), 2014, p.359–367 | ||||||| | 書誌情報 | American Journal of Reproductive Immunology 巻 71, 号 4, p. 359-367, 発行日 2014-04 | ||||||| | ISSN | |||||||| | 収録物識別子タイプ | ISSN | ||||||| | 収録物識別子 | 1046-7408 | ||||||| | DOI | |||||||| | 識別子タイプ | DOI | ||||||| | 関連識別子 | 10.1111/aji.12206 | ||||||| | 日本十進分類法 | |||||||| | 主題Scheme | NDC | ||||||| | 主題 | 495.43 | ||||||| | 著者版フラグ | |||||||| | 出版タイプ | ETD | ||||||| | その他のタイトル | |||||||| | その他のタイトル | 子宮内膜症における腹水中NK細胞のNatural Cytotoxicity Receptor発現とサイトカイン産生 | ||||||| | タイトル（ヨミ） | |||||||| | その他のタイトル | シキュウ ナイマクショウ ニオケル フクスイチュウ NK サイボウ ノ Natural Cytotoxicity Receptor ハツゲン ト サイトカイン サンセイ | ||||||| | NIIサブジェクト | |||||||| | 主題Scheme | Other | ||||||| | 主題 | 医学 | ||||||| | 出版者 | |||||||| | 出版者 | Wiley | ||||||| | 資源タイプ | |||||||| | 値 | Thesis | ||||||| | 学位名 | |||||||| | 学位名 | 博士（医学） | ||||||| | 学位授与機関 | |||||||| | 学位授与機関名 | 弘前大学 | ||||||| | 学位授与年月日 | |||||||| | 学位授与年月日 | 2014-03-20 | ||||||| | 学位授与番号 | |||||||| | 学位授与番号 | 甲1853 |

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interferon-gamma Killer Cells, Natural Natural Cytotoxicity Triggering Receptor 1 Tumor Necrosis Factor-alpha Adult Antigens, Surface Antigens, Surface Ascitic Fluid Ascitic Fluid Cell Proliferation Cytokines Cytokines Endometriosis Endometriosis Female Humans Interferon-gamma Killer Cells, Natural Laparoscopy

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