Killer Immunoglobulin‐like Receptor and Human Leukocyte Antigen Expression as Immunodiagnostic Parameters for Pelvic Endometriosis

Chunbin Zhang, Nagamasa Maeda, Chiaki Izumiya, Yorito Yamamoto, Tomoaki Kusume, Hiroyoshi Oguri, Chika Yamashita, Yoshiko Nishimori, Kazutoshi Hayashi, Jiabin Luo, Takao Fukaya
American journal of reproductive immunology (New York, N.Y. : 1989) · 2006 · vol. 55(2) , pp. 106–114 · doi:10.1111/j.1600-0897.2005.00332.x · PMID:16433829 · W2019782285
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This study found increased CD158a expression on NK cells and decreased HLA expression on macrophages in women with endometriosis, suggesting impaired immune function.

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Abstract

PROBLEM: We investigated host immunologic responses to endometriosis by comparing immune cell surface antigens in peripheral blood (PB) and peritoneal fluid (PF) from women with endometriosis with those in PB and PF from other patients. METHOD OF STUDY: Japanese women with endometriosis (n = 56) were compared with controls with other laparoscopic diagnoses (n = 68). PB and PF were collected at the time of laparoscopy for flow cytometry. RESULTS: No significant difference in phenotypic parameters of T cells (CD3, CD4, and CD8), B cells (CD19), natural killer (NK) cells (CD56), or monocytes/macrophages (CD14) was seen between women with and without endometriosis. However, increased killer immunoglobulin-like receptor (CD158a) expression by NK cells and decreased human leukocyte antigen (HLA)-ABC and -DR expression by macrophages, all suggesting decreased functional activation were found in endometriosis. These markers showed significant association with endometriosis by odds ratio, logistic regression, and decision tree analyses. CONCLUSIONS: Increased CD158a(+) NK cells in PB and PF indicated decreased NK cell cytotoxicity in endometriosis, while decreased HLA expression on PF macrophages suggested impaired antigen presentation. Thus, aberrant immune responses by NK cells and macrophages may represent risk factors for endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis HLA Antigens Leukocytes Pelvis Receptors, Immunologic Biomarkers Case-Control Studies Disease Susceptibility Endometriosis Female HLA Antigens Humans Leukocytes Receptors, Immunologic Receptors, KIR Receptors, KIR2DL1

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Cited by (35)

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