Innate Immune Cells: Gatekeepers of Endometriotic Lesions Growth and Vascularization

Annalisa Capobianco, Lucia Cottone, Antonella Monno, Stefano Ferrari, Paola Panina‐Bordignon, Angelo A. Manfredi, Patrizia Rovere‐Querini
In: Journal of Endometriosis · 2010 · vol. 2(2) , pp. 55–62 · doi:10.1177/228402651000200202 · W4237515386
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Infiltrating innate immune cells, particularly macrophages, are essential for endometriotic lesion growth, survival, and vascularization, making them potential therapeutic targets.

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Abstract

Infiltration by inflammatory leukocytes is a hallmark of all forms of endometriosis. Conversely, the innate immune system plays a key role in regulating events such as cell adhesion, migration, survival and neoangiogenesis of transformed or ectopic tissue. All these features are involved, and possibly required, in the development of endometriotic lesions. Recent data suggest that infiltrating leukocytes are not a mere epiphenomenon but represent an actual requirement for the development of the disease. In this scenario, the functional plasticity of infiltrating macrophages is a key event in the origin and maintenance of endometriotic lesions: the erroneous polarization of macrophages towards cells sustaining angiogenesis and tissue remodeling represents a potential target for novel molecular therapies.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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