Time course of pelvic endometriotic lesion revascularization in a nude mouse model

Julie Eggermont, Eggermont J, Donnez J, Jacques Donnez, Françoise Casanas‐Roux, Casanas-Roux F, Francoise Casanas-Roux, Hélène Scholtes, H.élène Scholtes, Scholtes H, Van Langendonckt A, Anne Van Langendonckt
Fertility and sterility · 2005 · vol. 84(2) , pp. 492–499 · doi:10.1016/j.fertnstert.2005.03.034 · PMID:16084895 · W2145485795
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This study investigated the timeline of blood vessel formation within pelvic endometriotic lesions in a nude mouse model.

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Abstract

ObjectiveTo assess the timing of endometrial lesion revascularization in a murine model.DesignProspective experimental study.SettingAn academic research environment.Animal(s)Twenty-six nude mice.Intervention(s)Endometriosis was induced in mice by intraperitoneal deposition of human menstrual endometrium. Endometrial implants were recovered on days 1, 3, 5, 8, 10, 15, and 21 after implantation.Main outcome measure(s)Sections from the endometrial implants were immunostained with species-specific antiplatelet endothelial cell adhesion molecule-1 (PECAM-1) antibodies and vessels of murine and human origin were counted.Result(s)Endothelial cells of human origin in the implant progressively disappeared between day 3 and day 10. Seventy-eight percent of the vessel sections were positive for human PECAM-1 on day 5, 40.1% on day 8, and only 14.1% on day 10. However, there was a marked increase in murine PECAM-1-expressing vessels in endometrial stroma between day 5 (1.4%) and day 8 (68.0%), 10 (69.5%), and 15 (87.2%).Conclusion(s)Our study demonstrates that PECAM-1 is a reliable endothelial cell marker to evaluate the role of angiogenesis in the nude mouse model. It also indicates that revascularization of human endometrial implants occurs between 5 and 8 days after implantation and involves the disappearance of native graft vessels, coinciding with the invasion of the interface and then the stroma by murine vessels.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Neovascularization, Pathologic Pelvis Animals Disease Models, Animal Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Mice Mice, Nude Neovascularization, Pathologic Neovascularization, Pathologic Pelvis Pelvis Pelvis

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