Circulating Endothelial Progenitor Cells Are Up-Regulated in a Mouse Model of Endometriosis
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In a mouse model of endometriosis, circulating endothelial progenitor cells were found to be up-regulated, suggesting a role in neovascularization.
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Abstract
Endometriosis is a debilitating disease characterized by the growth of ectopic endometrial tissue. It is widely accepted that angiogenesis plays an integral part in the establishment and growth of endometriotic lesions. Recent data from a variety of angiogenesis-dependent diseases suggest a critical role of bone marrow–derived endothelial progenitor cells (EPCs) in neovascularization. In this study the of and endothelial cells in a of of in the of that a the of endometriotic and of In a bone endothelial cells endometriotic by and of the angiogenesis an of data an role bone marrow–derived endothelial cells in the of and the of a this Endometriosis is a debilitating disease characterized by the growth of ectopic endometrial tissue. It is widely accepted that angiogenesis plays an integral part in the establishment and growth of endometriotic lesions. Recent data from a variety of angiogenesis-dependent diseases suggest a critical role of bone marrow–derived endothelial progenitor cells (EPCs) in neovascularization. In this study the of and endothelial cells in a of of in the of that a the of endometriotic and of In a bone endothelial cells endometriotic by and of the angiogenesis an of data an role bone marrow–derived endothelial cells in the of and the of a this of of disease debilitating and of and In is is of the of the endometriotic the and of a a and of of in of in and and of a of of the of of of endometriotic of the In the is the and is and of an the and In an of and a of Endometriosis and the the of the the of by and that the of a is the establishment and growth of endometriotic and in in of angiogenesis a of and in the growth of endometriotic of in a of of endothelial growth growth and growth of angiogenesis and in endometriotic a of of endothelial of in disease and of in and of endothelial cells endothelial cells from the bone of progenitor endothelial cells endothelial endothelial growth is in endometriotic and of endothelial growth in endothelial growth in of of endothelial growth in the angiogenesis the and in the of is a the of bone marrow–derived endothelial progenitor cells by bone endothelial progenitor in by of and and in by of endothelial growth in of the of of in and the of of the progenitor cells the in progenitor cells of and of endothelial and cells angiogenesis and endothelial and of and the of endothelial cells from of endothelial growth endothelial and endothelial a of that and disease and of in of the of and growth angiogenesis of in the of an of growth and in this study the role of of an of of and a bone the of the of endometriotic lesions. the of and and in the and in and and by the and of from from and from a from of cells of and bone in of and a of from of the of the by the growth of endometriotic the the in and Endometriosis the growth of endometriotic endothelial in and in a of in a the of in the the a and in a in of a and the the the endometrial the a a in the that of endometrial tissue. in the of the and the the of the of a the of a the growth of endometriotic and growth of in a of of the of the a In of the in a and of the an of the angiogenesis by and in and the of the the of In the bone bone endometriotic from progenitor cells In bone from and and bone bone the of the in bone by of and in the of of the of of by and of and of endothelial cells of endothelial growth endothelial and endothelial a of and the and of endothelial progenitor the endothelial growth of endothelial progenitor cells the the of cells in and endometriotic from that a bone and in the in and in and and in and the the a and data and and in endothelial angiogenesis by a and of endothelial growth endothelial and endothelial a of endothelial cells in and and bone marrow–derived progenitor endothelial cells of endothelial growth endothelial and endothelial a of and the and of endothelial progenitor the endothelial growth of endothelial progenitor endothelial in and and an in and in and and the and from in in and in that a and progenitor cells of and in of cells of and and the and data and data in of of the of of in a of the of in a of by in endometriotic lesions. of endothelial growth endothelial and endothelial a of by of endothelial and and the of and by and in a of and of of endothelial growth endothelial and endothelial a of progenitor cells In the of and a the the the and of the of of angiogenesis in of the of angiogenesis in a in the that a and the of the of endometriotic disease a in a in the and a from the in of and in the and of endothelial cells from endometriotic and endometriotic a the of an the growth of endometriotic endothelial in and in a and growth of in a of of the of in a and and and and and in that that a in the by the of bone cells in the in the endometriotic and in the and endometriotic and and endothelial cells by the of and and of a a in the of endothelial cells the endometriotic in cells in endometriotic lesions. bone from endometriotic from and from and and and of and endothelial cells of cells of cells of 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that growth disease establishment and the angiogenesis in of endothelial and and of in disease and and of angiogenesis in In the the of bone marrow–derived endothelial progenitor cells the of and the in a that the of the the role of in the and of of endothelial and cells angiogenesis and endothelial in and In that of endothelial cells in the bone marrow–derived of bone marrow–derived cells in the this the of bone marrow–derived endothelial cells a of in the in the of endothelial progenitor and the endothelial progenitor cells and in this in in a that cells of endometriotic in a endothelial cells the the and the that the of the endothelial cells in the data suggest that bone marrow–derived endothelial cells this of is a disease that of in the growth and in endometriotic of of endothelial growth in the angiogenesis the and in the of of growth in from in of is a endothelial cells and of It that plays a role in the of bone progenitor cells by bone endothelial progenitor that is of the the of in this data that in the the and in and by a the by a the In a in of and in the and growth of in a of of in the of and of the of of endometriotic in a in in the that a is in growth and growth by cells from of and progenitor cells from the bone of endothelial progenitor in the of and of in ectopic and of and of and of growth in the of endothelial cells in that a and in this in the that of the and in the of cells from the in that this in the this the in a that of the endothelial cells from the a role a in and in and the by angiogenesis a the of angiogenesis in and of angiogenesis in is an of of the by the angiogenesis and in and that the angiogenesis and the and of endometriotic growth the growth of endometriotic endothelial in and in a a is a angiogenesis that endometriotic of that angiogenesis and the of in the that in and study of and of an angiogenesis in in is an of the growth and angiogenesis in and endothelial cells the by and of and endothelial by in and the by the is by and study that the of in the of that growth of endometriotic lesions. a an of that endometriotic growth and of the of endothelial and of endothelial growth by the angiogenesis of by and endothelial and growth and endothelial growth In data suggest that by cells is by the of the of from the is a role in bone is that in the endometriotic in a progenitor that is in endometriotic and growth of in a of the this the in the In angiogenesis in a and in the of the is that the of the is that bone marrow–derived endothelial cells in a of the of angiogenesis in the establishment and growth of endometriotic and the that endothelial progenitor cells in the of the is the a and in the disease and the of endothelial progenitor and endothelial cells in and and of of disease debilitating and of and In is is of the of the endometriotic the and of a a and of of in of in and and of a of of the of of of endometriotic of the In the is the and is and of an the and In an of and a of Endometriosis and the the of the 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growth and in this study the role of of an of of and a bone the of the of endometriotic lesions. the of and and in the and in and and by the and of from from and from a from of cells of and bone in of and a of from of the of the by the growth of endometriotic the the in and Endometriosis the growth of endometriotic endothelial in and in a of in a the of in the the a and in a in of a and the the the endometrial the a a in the that of endometrial tissue. in the of the and the the of the of a the of a the growth of endometriotic and growth of in a of of the of the a In of the in a and of the an of the angiogenesis by and in and the of the the of In the bone bone endometriotic from progenitor cells In bone from and and bone bone the of the in bone by of and in the of of the of of by and of and of endothelial cells of endothelial growth endothelial and endothelial a of and the and of endothelial progenitor the endothelial growth of endothelial progenitor cells the the of cells in and 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