Serum levels of VEGF and TNF-α and their association with C-reactive protein in patients with endometriosis

Pedro Xavier, Luís Belo, Luı́s Belo, Jorge Beires, Irene Rebelo, José Martinez‐de‐Oliveira, José Martinez-de-Oliveira, Nuno Lunet, Henrique Barros
Archives of gynecology and obstetrics · 2005 · vol. 273(4) , pp. 227–231 · doi:10.1007/s00404-005-0080-4 · PMID:16208475 · W2023851164
article OA: closed CC0 ⤵ 79 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study found increased serum VEGF in secretory phases and TNF-α in all phases in endometriosis patients, with a positive correlation between CRP and VEGF.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This study followed 25 women with endometriosis (ASRM stage III–IV) and 13 controls across one menstrual cycle, measuring serum VEGF, TNF-α, and CRP by ELISA in early/late proliferative and early/late secretory phases. The authors reported increased serum VEGF during secretory phases and increased TNF-α across all cycle phases in the endometriosis group. They found a positive correlation between CRP and VEGF in endometriosis patients, but not in controls. A key limitation explicitly reflected by the design is the small sample size and the single-cycle follow-up, which constrains generalizability. This paper is centrally about endometriosis — it quantifies cyclic changes in VEGF and TNF-α and their association with CRP in patients with endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

C-Reactive Protein Endometriosis Menstrual Cycle Tumor Necrosis Factor-alpha Vascular Endothelial Growth Factor A Adult C-Reactive Protein Endometriosis Female Humans Menstrual Cycle Tumor Necrosis Factor-alpha Vascular Endothelial Growth Factor A

Citation neighborhood

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References (27)

Cited by (50)

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