Endometriosis: abnormal endometrium and dysfunctional immune response

Braun DP, Donald P. Braun, D P Braun, Dmowski WP, W. Paul Dmowski, W P Dmowski
Current opinion in obstetrics & gynecology · 1998 · vol. 10(5) , pp. 365–369 · doi:10.1097/00001703-199810000-00003 · PMID:9818213 · W2152421826
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This review discusses recent findings on the immune system's role in endometriosis, proposing that apoptosis-resistant endometrial cells use immune products to form ectopic foci, leading to progressive immunological derangement.

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This review article examines the role of the immune system in endometriosis through a model proposing that the disease results from an immunological selection process. It describes how endometrial cells, which are resistant to apoptosis and immune elimination, exploit products from an activated immune system to establish ectopic disease foci. The authors note that cyclical inflammatory stimulation failing to clear these implants leads to progressive immunological derangement and characteristic pathophysiological changes. This paper is centrally about endometriosis — specifically focusing on the interplay between abnormal endometrium and dysfunctional immune responses in its pathogenesis.

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Abstract

This review highlights recent studies that illuminate the role of the immune system in endometriosis. The findings are discussed in the framework of a model which proposes that endometriosis reflects an immunological selection process. Endometrial cells, which are inherently resistant to apoptosis and immune-mediated elimination, acquire the capacity to utilize the products of an activated immune system to establish ectopic foci of disease. Cyclical inflammatory/immune cell stimulation that fails to eliminate ectopic endometrial implants results in progressive immunological derangement and associated pathophysiological changes which are characteristic of the disease.
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Review Article Endometriosis: abnormal endometrium and dysfunctional immune response - Donald P. Braun - W. Paul Dmowski Current Opinion in Obstetrics & Gynecology 10(5):p 365-369, October 1998. This review highlights recent studies that illuminate the role of the immune system in endometriosis. The findings are discussed in the framework of a model which proposes that endometriosis reflects an immunological selection process. Endometrial cells, which are inherently resistant to apoptosis and immune-mediated elimination, acquire the capacity to utilize the products of an activated immune sytem to establish ectopic foci of disease. Cyclical inflammatory/immune cell stimulation that fails to eliminate ectopic endometrial implants results in progressive immunological derangement and associated pathophysiological changes which are characteristic of the disease. Copyright © 1998 Lippincott Williams & Wilkins, Inc.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Endometriosis Endometrium Endometrium Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (32)

Cited by (50)

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License: CC0 · commercial use OK