Endometriosis: abnormal endometrium and dysfunctional immune response
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This review discusses recent findings on the immune system's role in endometriosis, proposing that apoptosis-resistant endometrial cells use immune products to form ectopic foci, leading to progressive immunological derangement.
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Abstract
This review highlights recent studies that illuminate the role of the immune system in endometriosis. The findings are discussed in the framework of a model which proposes that endometriosis reflects an immunological selection process. Endometrial cells, which are inherently resistant to apoptosis and immune-mediated elimination, acquire the capacity to utilize the products of an activated immune system to establish ectopic foci of disease. Cyclical inflammatory/immune cell stimulation that fails to eliminate ectopic endometrial implants results in progressive immunological derangement and associated pathophysiological changes which are characteristic of the disease.
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Cited by (50)
- Exploring Endometriosis Awareness Levels among Married Women Residing in Rural Communities of Sundargarh District of Odisha 2024
- The role and potential treatment of macrophages in patients with infertility and endometriosis 2024
- A Preliminary Investigation of the Roles of Endometrial Cells in Endometriosis Development via In Vitro and In Vivo Analyses 2024
- Integrated analysis identified novel miRNAs and mRNA in endometriosis 2022
- Re-evaluation of mouse models of endometriosis for pathological and immunological research 2022
- Histotyping and grading of endometriosis and its association with clinico-pathological parameters 2022
- Brief Review of Endometriosis and the Role of Trace Elements 2021
- The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Development and/or Progression of Endometriosis-State of the Art 2021
- Upregulation of fibroblast growth factor 2 contributes to endometriosis through SPRYs/DUSP6/ERK signaling pathway 2021
- Endometriotic lesions 2019
- Higher Prevalence of Endometrial Polyps in Infertile Patients with Endometriosis 2018
- The role of selected populations of immune cells in the pathogenesis of endometriosis 2018
- Higher prevalence of chronic endometritis in women with endometriosis: a possible etiopathogenetic link 2017
- Cervical mucus proteome in endometriosis 2017
- Protein‑protein interaction analysis to identify biomarker networks for endometriosis 2017
- Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women 2016
- Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis 2016
- Correlation between dioxin and endometriosis: an epigenetic route to unravel the pathogenesis of the disease 2015
- Pain related genes in endometriosis: A meta-analysis 2015
- The Role of the Lymphatic System in Endometriosis: A Comprehensive Review of the Literature1 2015
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- The Association between Endometriosis and Chronic Endometritis 2014
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- Evidence of neurotrophic events due to peritoneal endometriotic lesions 2013
- Anti-TNF-α treatment for pelvic pain associated with endometriosis 2013
- Endometriosis 2013
- Immunology of Normal and Abnormal Menstruation 2013
- Expression of human b-defensin-2 in the eutopic and ectopic endometrial tissues in patients with endometriosis 2013
- Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis 2012
- Gynecologic Etiologies of Chronic Pelvic Pain 2012
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- Pentoxifylline for endometriosis 2012
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- Endometriosis for the Colorectal Surgeon 2010
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