Cytolysis of Eutopic and Ectopic Endometrial Cells by Peripheral Blood Monocytes and Peritoneal Macrophages in Women with Endometriosis

D P Braun, Braun DP, Donald P. Braun, Howard M. Gebel, Gebel H, H Gebel, Nasir Rana, N Rana, Rana N, Dmowski WP, W. Paul Dmowski, W P Dmowski
Fertility and sterility · 1998 · vol. 69(6) , pp. 1103–1108 · doi:10.1016/s0015-0282(98)00062-4 · PMID:9627300 · W1981241107
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Peripheral blood monocytes and peritoneal macrophages from women with endometriosis exhibit cytolytic activity against both eutopic and ectopic endometrial cells.

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Abstract

ObjectiveTo compare the ability of peripheral blood monocytes (PBM) and peritoneal macrophages (PM) to mediate the in vitro cytolysis of endometrial cells from eutopic and ectopic endometrium in women with endometriosis.DesignProspective study of immune function.SettingInstitute for the Study and Treatment of Endometriosis and university-based research laboratories.Patient(s)Twenty-four women with endometriosis (15 in stage I/II, 9 in stage III/IV) and 4 patients treated with GnRH agonists.Intervention(s)Peritoneal fluid and peripheral blood were sampled and eutopic and ectopic endometrium were biopsied during diagnostic laparoscopy.Main outcome measure(s)Lysis of autologous endometrial cells.Result(s)Peripheral blood monocytes were significantly more cytolytic than peritoneal macrophages against autologous uterine endometrial cells. However, PBM and PM displayed a similar degree of cytolysis against a hepatoma cell line. Ectopic endometrial cells were significantly more resistant to cytolysis by autologous PBMC than were matched eutopic endometrial cells, and were completely resistant to cytolysis by autologous PM.Conclusion(s)The reduced capacity of PM from women with endometriosis to mediate the destruction of endometrial cells coupled with the increased resistance of ectopic endometrial cells to macrophage-mediated cytolysis may facilitate the survival of these cells within the peritoneal cavity of women with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cytotoxicity, Immunologic Endometriosis Endometriosis Endometrium Endometrium Macrophages, Peritoneal Monocytes Adult Cytotoxicity, Immunologic Endometriosis Endometrium Female Humans Macrophages, Peritoneal Monocytes Prospective Studies Tumor Cells, Cultured Tumor Cells, Cultured

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