Proteomics and the search for biomarkers of female reproductive diseases

Katie L Meehan, Katie Meehan, Adam Rainczuk, Lois A Salamonsen, Andrew N Stephens
Reproduction (Cambridge, England) · 2010 · vol. 140(4) , pp. 505–519 · doi:10.1530/rep-10-0226 · PMID:20628032 · W2054542006
review OA: bronze CC0 ⤵ 12 in-corpus citations
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Abstract

Over the past decade, high-throughput proteomics technologies have evolved considerably and have become increasingly more commonly applied to the investigation of female reproductive diseases. Proteomic approaches facilitate the identification of new disease biomarkers by comparing the abundance of hundreds of proteins simultaneously to find those specific to a particular clinical condition. Some of the best studied areas of female reproductive biology applying proteomics include gynaecological cancers, endometriosis and endometrial infertility. This review will discuss the progress that has been made in these areas and will highlight some of the emerging technologies that promise to contribute to better understanding of the female reproductive disease.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Biomarkers Genital Diseases, Female Proteomics Biomarkers Electrophoresis, Gel, Two-Dimensional Electrophoresis, Gel, Two-Dimensional Endometriosis Female Genital Diseases, Female Genital Diseases, Female Humans Mass Spectrometry Mass Spectrometry Proteomics

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