Detection of endometriosis with the use of plasma protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

Liu H, Haiyuan Liu, Jinghe Lang, Lang J, Zhou Q, Qunfang Zhou, Dan Shan, Shan D, Qizhai Li, Li Q
Fertility and sterility · 2007 · vol. 87(4) , pp. 988–990 · doi:10.1016/j.fertnstert.2006.08.095 · PMID:17207800 · W2052601696
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Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry identified 20 distinct protein peaks in plasma, enabling a diagnostic classifier with 87.5% sensitivity and 80% specificity for endometriosis.

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Abstract

In this prospective case-control study, we determined the role of surface-enhanced laser desorption and ionization time-of-flight mass spectrometry in the detection of histologically proven endometriosis. In the plasma of the group with endometriosis, there were 20 different protein peaks, and the classifier showed a sensitivity of 87.5% and a specificity of 80% in the diagnosis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Blood Proteins Endometriosis Proteomics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Adult Blood Proteins Case-Control Studies Endometriosis Endometriosis Female Humans Middle Aged Prospective Studies Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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