Surface-Enhanced Laser Desorption/Ionization Mass Spectrometry of Peritoneal Fluid Identifies Potential Biomarkers for Endometriosis

Monika Wölfler, Corinna Henkel, Daniela Hornung, Ruth Knüchel, Werner Rath, Nicolaì Maass, Kristina Schwamborn
In: Journal of Endometriosis · 2009 · vol. 1(3-4) , pp. 131–136 · doi:10.1177/2284026509001003-403 · W4232639405
article OA: closed CC0 ⤵ 1 in-corpus citation
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Surface-enhanced laser desorption/ionization mass spectrometry of peritoneal fluid identified 16 protein peaks that predict endometriosis with 85.2% accuracy.

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Abstract

Purpose Several markers for diagnosis of endometriosis that have been tested in clinical approaches so far lack in both sensitivity and specificity. Therefore, it is conceivable that a need exists to perform a cluster analysis in which the attributes of different markers are considered. Methods In this study, protein pattern profiling by surface-enhanced laser desorption/ionization time of flight (SELDI-TOF) mass spectrometry was performed to reveal differentially expressed pathognomonic proteins for endometriosis in peritoneal fluid samples of 106 symptomatic patients. Results At laparoscopy, 46 out of 106 (43.4%) patients exhibited endometriosis and 60 (56.6%) were proven disease-free. Using anionic affinity surfaces and a genetic algorithm for data analysis, 16 significantly different protein peaks were identified that allow for the prediction of endometriosis, with an overall recognition capability of 85.2%, exhibiting a sensitivity of 70.6% and a specificity of 80.8%. Conclusions Although lacking in sensitivity, this study provides highly significant information about differentially regulated proteins in endometriosis which might play a key role in the pathogenesis of this disease.

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endometriosis

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