Is Endometriosis Associated with Systemic Subclinical Inflammation?

Admir Agic, Agic A, Xu H, Hong Xu, Dominique Finas, D. Finas, Finas D, Constanze Banz, Banz C, Klaus Diedrich, Diedrich K, Daniela Hornung, Hornung D
Gynecologic and obstetric investigation · 2006 · vol. 62(3) , pp. 139–147 · doi:10.1159/000093121 · PMID:16679772 · W1991579675
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Endometriosis is associated with elevated peripheral blood levels of inflammatory markers like CRP and cytokines, and altered monocyte and lymphocyte counts, indicating systemic subclinical inflammation.

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Abstract

Endometriosis is a pelvic inflammatory process with altered function of immune-related cells and increased number of activated macrophages in the peritoneal environment that secrete various local products, such as growth factors and cytokines. The elevation of cytokines and other factors in the peritoneal fluid is accompanied by the elevation of similar factors, such as CRP, SAA, TNF-alpha, MCP-1, IL-6, IL-8 and CCR1, in the peripheral blood of patients with endometriosis. CD44+ and CD14+ monocytes are significantly increased, while CD3+ T lymphocytes and CD20+ B lymphocytes show modest, but significant decrease in peripheral blood of women with endometriosis. This indicates that endometriosis could be viewed as a local disease with systemic subclinical manifestations. This review provides an overview of data on the changes of various factors in peripheral blood and their potential use as diagnostic tools in patients with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Endometriosis Endometriosis Ascitic Fluid Ascitic Fluid Biomarkers Chemokine CCL2 Chemokine CCL2 Chemokine CCL5 Chemokine CCL5 C-Reactive Protein C-Reactive Protein Endometriosis Endometriosis Female Humans Inflammation Intercellular Adhesion Molecule-1 Intercellular Adhesion Molecule-1 Interleukins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (78)

Cited by (50)

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