Do Soluble Cell Adhesion Molecules Play a Role in Endometriosis?
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This study found significantly increased serum levels of soluble intercellular cell adhesion molecule-1 (sICAM-1) in women with endometriosis compared to healthy controls.
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Abstract
PROBLEM: Endometriosis is a chronic inflammatory disease associated with diverse immunologic disturbances. Cell adhesion molecules are essential for the development of immune and inflammatory reactions. This study was conducted to investigate whether or not serum and peritoneal levels of soluble cell adhesion molecules are altered in women with endometriosis. METHOD OF STUDY: The study group comprised five women with moderate‐to‐severe endometriosis. Eight healthy women with a normal diagnostic laparoscopy served as controls. Serum and peritoneal fluid samples from both groups were analyzed for the soluble isoform of intercellular cell adhesion molecule‐1 (sICAM‐1), vascular cell adhesion molecule‐1 (sVCAM‐1), endothelial selectin (sES), and platelet selectin (sPS). RESULTS: Serum levels of sICAM‐1 were significantly increased in women with endometriosis (median levels: 410.4 ng/mL; range: 233.9 ng/mL–598.4 ng/mL vs. 235.7 ng/mL; range: 187.4 ng/mL–323.7 ng/mL; P= 0.02). Although the levels of sVCAM‐1, sES, and sPS in both samples were higher in the study group, the differences did not reach significance. CONCLUSIONS: Our results suggest a role of ICAM‐1 in the pathophysiology of endometriosis. However, the role of other investigated cell adhesion molecules should be confirmed by further studies.
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Cited by (31)
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- The role of monocyte to high-density lipoprotein cholesterol ratio in prediction of increased systemic inflammation and the risk of cardiovascular disease in endometriosis 2021
- Does the Use of the “Proseek® Multiplex Oncology I Panel” on Peritoneal Fluid Allow a Better Insight in the Pathophysiology of Endometriosis, and in Particular Deep-Infiltrating Endometriosis? 2020
- The link between immunity, autoimmunity and endometriosis: a literature update 2018
- Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture 2018
- Soluble VCAM-1/soluble ICAM-1 ratio is a promising biomarker for diagnosing endometriosis 2017
- Decoy receptor 3 promotes cell adhesion and enhances endometriosis development 2017
- P-selectin levels in women with endometriosis and non-endometriosis 2017
- How to Understand the Complexity of Endometriosis-Related Pain 2017
- Identifying biomarkers for non-invasive diagnosis of endometriosis 2016
- rhTNFR: Fc Suppresses the Development of Endometriosis in a Mouse Model by Downregulating Cell Proliferation and Invasiveness 2015
- Using Symptom Scores, Lifestyle Measures and Biochemical Markers to Create a Test for Endometriosis 2014
- Endometriosis and the Enigmatic Question of Progression 2014
- Endometriosis 2013
- Inflammation and Endometriosis 2011
- Useful Biomarkers for the Diagnosis of Endometriosis 2010
- Peripheral biomarkers of endometriosis: a systematic review 2010
- Endometriosis 2009
- Nerve fibres in ovarian endometriotic lesions in women with ovarian endometriosis 2009
- Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach 2007
- Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis 2007
- Endometriosis and Genetic Polymorphisms 2007
- Is Endometriosis Associated with Systemic Subclinical Inflammation? 2006
- Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? 2006
- Peritoneal fluid cytokines and sICAM-1 in minimal endometriosis: search for discriminating factors between infertility and/or endometriosis 2005
- Concentration of soluble intercellular adhesion molecule-1 in serum samples from patients with endometriosis collected during the luteal phase of the menstrual cycle 2003
- The Role of Cytokines in Endometriosis* 2003
- Serum and Peritoneal Markers for Endometriosis 2003
- Enhanced T cells interactions with extracellular matrix proteins in infertile women with endometriosis 2002
- A defective expression of ICAM-1 (CD54) on secretory endometrial cells is associated with endometriosis 2002
- Oxidative stress and peritoneal endometriosis 2002
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