The link between immunity, autoimmunity and endometriosis: a literature update

Tao Zhang; Caterina De Carolis; De Carolis C; Gene Chi Wai Man; Chi Chiu Wang

doi:10.1016/j.autrev.2018.03.017

The link between immunity, autoimmunity and endometriosis: a literature update

Tao Zhang, Caterina De Carolis, De Carolis C, Gene Chi Wai Man, Chi Chiu Wang

Autoimmunity reviews · 2018 · vol. 17(10) , pp. 945–955 · doi:10.1016/j.autrev.2018.03.017 · PMID:30107265 · W2885973292

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This literature update reviews the connections between immunity, autoimmunity, and endometriosis, synthesizing current understanding of these complex relationships.

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Abstract

Endometriosis (EMS), an estrogen-dependent inflammatory disorder affects approximately 5-10% of the general female population of reproductive age and 20-90% of women with pelvic pain and infertility. Many immunological factors are known to contribute significantly to the pathogenesis and pathophysiology of EMS, and both chronic local inflammation and autoantibodies in EMS shares many similarities with autoimmune diseases (AD). However, the autoimmune etiology in EMS remains controversial, and its evidence on autoimmune basis may be limited. Here we aim to review the current understanding between autoimmunity and EMS to provide important knowledge to develop future potential immunomodulatory therapy for the treatment of EMS.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Animals Autoimmunity Cytokines Cytokines Endometriosis Endometriosis Female Humans Inflammation Inflammation

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

Source provenance

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