[Study on polymorphism of human leukocyte antigen-DRB1 allele in patients with endometriosis].

Xin Wang, Chunyu Liu, Qiuhua Lin, Lin Qiu-hua, Xiaoling Fang, Li Lin, Qiyuan Mei
Zhonghua fu chan ke za zhi · 2002 · vol. 37(6) , pp. 346–8 · PMID:12126569 · W2389014996
article OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found a significant correlation between the HLA-DRB1 15 allele and endometriosis occurrence, suggesting it may be a pathogenic factor.

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Abstract

OBJECTIVE: To study the possibility of a correlation between occurrence of endometriosis (EM) and polymorphism of human leukocyte antigen (HLA) DRB1 allele. METHODS: Polymorphism of HLA-DRB1 allele were detected by polymerase chain reaction- sequence specific primers (PCR-SSP) testing 40 surgically proven EM patients and 50 normal control. RESULTS: At HLA-DRB1 15 allele, positive frequency of EM group was significant higher as compared with those of the normal control group [45.0% vs 26.0%, P < 0.05, relative risk (RR) = 2.1]. Other HLA-DRB1 allele positive frequency of EM group and control group had no significant difference. But for Polymorphism of DRB1 * 15 allele, positive frequency of EM group and control group had no significant difference [1501 : 35.0% vs 20.0%; 1502 : 10.0% vs 6.0%; P > 0.05]. CONCLUSIONS: The occurrence of EM may be associated with the presence of HLA-DRB1 allele, but hasn't associated about polymorphism of DRB1* 15 allele. HLA-DRB1 * 15 maybe one of some factors for the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis HLA-DR Antigens Polymorphism, Genetic Adult Alleles Endometriosis Endometriosis Female Gene Frequency HLA-DR Antigens HLA-DRB1 Chains Humans Middle Aged Polymerase Chain Reaction Polymerase Chain Reaction

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