The Endobiota-estrobolome Study in Reproductive aged Women with Ovarian Endometriosis

Chao Hu, Angel Hsin-Yu Pai, Yiwen Wang, Pei‐Chen Lu, Hsien‐Ming Wu, Hong-Yuan Huang
In: Research Square · 2024 · doi:10.21203/rs.3.rs-4975125/v1 · W4403493447
preprint OA: green CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study analyzed enzymatic expressions, bacterial compositions, and estrogen metabolites in fecal, vaginal, and urinary samples of women with and without ovarian endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This case-control preprint studied women of reproductive age (24 with pathologically proven ovarian endometriosis vs 14 controls) using pre-surgery fecal, urine, and vaginal samples to assess gut β-glucuronidase/β-glucosidase activity, estrogen metabolites (14 targets) by LC-MS/MS, and gut/vaginal microbiota composition by 16S rRNA gene sequencing. The authors found broadly similar fecal β-glucuronidase activity, microbial diversity, and abundance between groups, but controls had higher prevalence of Rothia whereas multiple genera were more abundant in the ovarian endometriosis group; vaginal samples from endometriosis patients additionally showed lower bacterial abundance, diversity, richness, and evenness, along with lower folds of several estrogen metabolites (4-methoxyestrone, 2-methoxyestrone, and 2-hydroxyestrone-3-methyl ether). A stated limitation is that the study did not demonstrate “obvious dysbiosis,” and it has other constraints typical of a small single-cohort case-control design with limited sample sizes for sequencing and metabolites. This paper is centrally about endometriosis — specifically, ovarian endometriosis and its associations with the endobiota/“estrobolome” (microbiota, β-glucuronidase, and estrogen metabolites) across fecal and vaginal compartments.

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Outcome instruments

rASRM Enzian

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (57)

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