Gut Microbiome–Estrobolome Profile in Reproductive-Age Women with Endometriosis

Angel Hsin-Yu Pai, Yiwen Wang, Yi-Wen Wang, Pei-Chen Lu, Pei‐Chen Lu, Hsien‐Ming Wu, Jia-Ling Xu, Jialing Xu, Hong-Yuan Huang
International journal of molecular sciences · 2023 · vol. 24(22) , pp. 16301 · doi:10.3390/ijms242216301 · PMID:38003489 · W4388655277
article OA: gold CC0 ⤵ 17 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that women with endometriosis had enriched Erysipelotrichia in their gut microbiota and higher levels of certain estrogen metabolites in fecal samples, despite no significant differences in overall microbial diversity or β-glucuronidase activity.

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Abstract

Microbiota is associated with our bodily functions and microenvironment. A healthy, balanced gut microbiome not only helps maintain mucosal integrity, prevents translocation of bacterial content, and contributes to immune status, but also associates with estrogen metabolism. Gut dysbiosis and estrobolome dysfunction have hence been linked to certain estrogen-dependent diseases, including endometriosis. While prior studies on microbiomes and endometriosis have shown conflicting results, most of the observed microbial differences are seen in the genital tract. This case-control study of reproductive-age women utilizes their fecal and urine samples for enzymatic, microbial, and metabolic studies to explore if patients with endometriosis have distinguishable gut microbiota or altered estrogen metabolism. While gut β-glucuronidase activities, microbial diversity, and abundance did not vary significantly between patients with or without endometriosis, fecal samples of patients with endometriosis were more enriched by the Erysipelotrichia class and had higher folds of four estrogen/estrogen metabolites. Further studies are needed to elucidate what these results imply and whether there indeed is an association or causation between gut microbiota and endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Gastrointestinal Microbiome Gastrointestinal Microbiome Gastrointestinal Microbiome Gastrointestinal Microbiome Gastrointestinal Microbiome Microbiota Microbiota Microbiota Microbiota Microbiota Case-Control Studies Case-Control Studies Case-Control Studies Case-Control Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (59)

Cited by (17)

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