Endometriosis: recent advances that could accelerate diagnosis and improve care

Meaghan J. Griffiths; Andrew W. Horne; Douglas A Gibson; Neil Roberts; Roberts N; Philippa T. K. Saunders

doi:10.1016/j.molmed.2024.06.008

Endometriosis: recent advances that could accelerate diagnosis and improve care

Meaghan J. Griffiths, Andrew W. Horne, Douglas A Gibson, Neil Roberts, Roberts N, Philippa T. K. Saunders

Trends in molecular medicine · 2024 · vol. 30(9) , pp. 875–889 · doi:10.1016/j.molmed.2024.06.008 · PMID:38991858 · W4400484339

review OA: hybrid CC0 ⤵ 22 in-corpus citations

🔓 Open OA copy View on OpenAlex View on PubMed View at publisher

⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This review details recent advances in imaging, infertility mechanisms, drug therapies, and gut insights that may accelerate diagnosis and improve multi-system care for endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a common disorder associated with pain, gastrointestinal and urinary symptoms, infertility, and fatigue. It is defined by the presence of endometrial-like lesions found predominantly in the pelvis. Mechanisms that contribute to disease aetiology include changes in hormonal, inflammatory, and pain pathways. In this article, we focus on recent developments in imaging technologies, on our improved understanding of mechanisms contributing to infertility, on drug therapies that are in clinical trials, and on insights from studies on the gut that offer potential to support self-management strategies. We postulate that improvements in the quality of life of patients will be accelerated by reframing endometriosis as a multi-system disorder and learning from treatments targeting symptoms shared between endometriosis, neuroinflammatory, and gastrointestinal disorders.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (28)

Source provenance

europepmc: last seen: 2026-09-10T06:15:44.054944+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-09-10T06:13:11.153110+00:00

License: CC0 · commercial use OK

[1] A Bioinformatics Approach to MicroRNA-Sequencing Analysis Based on Human Saliva Samples of Patients with Endometriosis via openalex

[2] A long-acting anti-IL-8 antibody improves inflammation and fibrosis in endometriosis via openalex

[3] Are Adenomyosis and Endometriosis Phenotypes of the Same Disease Process? via openalex

[4] Associations Between Endometriosis and Gut Microbiota via openalex

[5] Cannabis and Endometriosis: The Roles of the Gut Microbiota and the Endocannabinoid System via openalex

[6] Catheter-directed Sclerotherapy for Ovarian Endometrioma: Short-term Outcomes via openalex

[7] Changing prostaglandin E2 (PGE<sub>2</sub>) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE<sub>2</sub> receptor EP2 and EP4 via openalex

[8] Circulating microRNAs as Non-Invasive Biomarkers in Endometriosis Diagnosis-A Systematic Review via openalex

[9] Comparison of the Effect on the Ovarian Reserve of Modern Methods of Treatment of Endometrioid Cysts via openalex

[10] Comparison of the impact of single-port laparoscopic and conventional laparoscopic ovarian cystectomy on the ovarian reserve in adult patients with benign ovarian cysts via openalex

[11] Cyclooxygenase-2 in Endometriosis via openalex

[12] Dietary Practices of Women with Endometriosis: A Cross-Sectional Survey via openalex

[13] Do ovarian endometriomas affect ovarian response to ovarian stimulation for IVF/ICSI? via openalex

[14] Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies via openalex

[15] Effect of early inflammatory reaction on ovarian reserve after laparoscopic cystectomy for ovarian endometriomas via openalex

[16] Effect of laparoscopic cystectomy on ovarian reserve in patients with ovarian cyst via openalex

[17] Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study via openalex

[18] Endometriosis and Adverse Pregnancy Outcomes: A Nationwide Population-Based Study via openalex

[19] Endometriosis and IVF treatment outcomes: unpacking the process via openalex

[20] Endometriosis and nuclear receptors via openalex

[21] Endometriosis Classification Systems: An International Survey to Map Current Knowledge and Uptake via openalex

[22] Endometriosis in patients with irritable bowel syndrome: Specific symptomatic and demographic profile, and response to the low FODMAP diet via openalex

[23] Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality via openalex

[24] ENDO_STAGE Magnetic Resonance Imaging: Classification to Screen Endometriosis via openalex

[25] Estrogen biosynthesis and signaling in endometriosis via openalex

[26] Ethanol Sclerotherapy versus Laparoscopic Surgery in Management of Ovarian Endometrioma; a Randomized Clinical Trial via openalex

[27] Evaluation of 18FDG PET-CT in the Diagnosis of Endometriosis: A Prospective Study via openalex

[28] Evaluation of Serum AMH, INHB Combined with Basic FSH on Ovarian Reserve Function after Laparoscopic Ovarian Endometriosis Cystectomy via openalex

[29] Evidence of shared genetic factors in the etiology of gastrointestinal disorders and endometriosis and clinical implications for disease management via openalex

[30] FDG-PET value in deep endometriosis via openalex

[31] Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis via openalex

[32] Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression via openalex

[33] Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality via openalex

[34] Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways via openalex

[35] Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium via openalex

[36] Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk via openalex

[37] Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function via openalex

[38] Gluten-free diet: a new strategy for management of painful endometriosis related symptoms? via openalex

[39] Guideline No. 449: Diagnosis and Impact of Endometriosis - A Canadian Guideline via openalex

[40] Gut Microbiome-Estrobolome Profile in Reproductive-Age Women with Endometriosis via openalex

[41] Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis via openalex

[42] Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis1 via openalex

[43] Identification of key modules and candidate genes associated with endometriosis based on transcriptome data via bioinformatics analysis via openalex

[44] Identification of lesional attributes of dysmenorrhea severity and the serum antimüllerian hormone levels in women with ovarian endometriomas via openalex

[45] Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis via openalex

[46] Impact of endometrioma and bilaterality on IVF / ICSI cycles in patients with endometriosis via openalex

[47] Impact of Laparoscopic Sclerotherapy for Ovarian Endometriomas on Ovarian Reserve via openalex

[48] Impact of Ovarian Endometrioma and Surgery on Reproductive Outcomes: A Single-Center Spanish Cohort Study via openalex

[49] Inhibition of receptor activity–modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels via openalex

[50] In Search of an Imaging Classification of Adenomyosis: A Role for Elastography? via openalex

[51] Insights from genomic studies on the role of sex steroids in the aetiology of endometriosis via openalex

[52] Intra-uterine microbial colonization and occurrence of endometritis in women with endometriosis† via openalex

[53] Investigation of anti-mullerian hormone (AMH) level and ovarian response in infertile women with endometriosis in IVF cycles. via openalex

[54] Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients: randomized, double-blind, placebo-controlled study via openalex

[55] Laparoscopic surgeries for uterine fibroids and ovarian cysts reduce ovarian reserve via age- and surgical type-manner via openalex

[56] Loss of HDAC3 results in nonreceptive endometrium and female infertility via openalex

[57] Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together-A Review via openalex

[58] Molecular and preclinical basis to inhibit PGE <sub>2</sub> receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis via openalex

[59] Multicenter evaluation of blood-based biomarkers for the detection of endometriosis and adenomyosis: A prospective non-interventional study via openalex

[60] New concepts on the etiology of endometriosis via openalex

[61] Noninvasive diagnostic imaging for endometriosis part 2: a systematic review of recent developments in magnetic resonance imaging, nuclear medicine and computed tomography via openalex

[62] Non-invasive imaging techniques for diagnosis of pelvic deep endometriosis and endometriosis classification systems: an International Consensus Statement via openalex

[63] Novel dietary supplement association reduces symptoms in endometriosis patients via openalex

[64] Nutritional practices and dietetic provision in the endometriosis population, with a focus on functional gut symptoms via openalex

[65] One‐year follow‐up of ovarian reserve by three methods in women after laparoscopic cystectomy for endometrioma and benign ovarian cysts via openalex

[66] Ovarian Endometrioma Negatively Impacts Oocyte Quality and Quantity But Not Pregnancy Outcomes in Women Undergoing IVF/ICSI Treatment: A Retrospective Cohort Study via openalex

[67] Ovarian reserve and recurrence 1 year post-operatively after using haemostatic sealant and bipolar diathermy for haemostasis during laparoscopic ovarian cystectomy via openalex

[68] Ovarian reserve in women with endometriosis under total cystectomy compared to partial cystectomy: A randomized clinical trial via openalex

[69] Overexpression and Functional Relevance of Somatostatin Receptor-1, -2, and -5 in Endometrium and Endometriotic Lesions via openalex

[70] Pathophysiology, diagnosis, and management of endometriosis via openalex

[71] Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility via openalex

[72] Progesterone Resistance in Endometriosis: an Acquired Property? via openalex

[73] Revised American Society for Reproductive Medicine classification of endometriosis: 1996 via openalex

[74] Risk Factors for Anti Mullerian Hormone Decline after Laparoscopic Excision of Endometrioma: A Prospective Study via openalex

[75] Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis via openalex

[76] Selective modulation of the prostaglandin F2α pathway markedly impacts on endometriosis progression in a xenograft mouse model via openalex

[77] Serum anti-Mullerian hormone, prolactin and estradiol concentrations in infertile women with endometriosis via openalex

[78] Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity via openalex

[79] SnapShot: Endometriosis via openalex

[80] Surgery for endometriomas within the context of infertility treatment via openalex

[81] The Clinical Outcome of Laparoscopic Surgery for Endometriosis on Pain, Ovarian Reserve, and Cancer Antigen 125 (CA-125): A Cohort Study. via openalex

[82] The effect of endometriosis on the antimüllerian hormone level in the infertile population via openalex

[83] The Pathogenesis of Adenomyosis vis-à-vis Endometriosis via openalex

[84] The presence of ovarian endometrioma adversely affect ovarian reserve and response to stimulation but not oocyte quality or IVF/ICSI outcomes: a retrospective cohort study via openalex

[85] Therapeutic Efficacy of Catheter-directed Ethanol Sclerotherapy and Its Impact on Ovarian Reserve in Patients with Ovarian Endometrioma at Risk of Decreased Ovarian Reserve: A Preliminary Study via openalex

[86] The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain via openalex

[87] Time for global health policy and research leaders to prioritize endometriosis via openalex

[88] Top ten endometriosis research priorities in the UK and Ireland via openalex

[89] Validation of a Salivary miRNA Signature of Endometriosis - Interim Data via openalex

[90] Value of the 68Ga-DOTATATE PET-CT in the diagnosis of endometriosis. A pilot study via openalex

[91] Whole-Tissue Deconvolution and scRNAseq Analysis Identify Altered Endometrial Cellular Compositions and Functionality Associated With Endometriosis via openalex

[92] W4311766488 via openalex

[93] W4214754424 via openalex

[94] W4313830852 via openalex

[95] W2910025422 via openalex

[96] W4206901134 via openalex

[97] W4200356756 via openalex

[98] W4323294151 via openalex

[99] W4324045019 via openalex

[100] W4380590751 via openalex