Factores de riesgo de desarrollo de dolor pélvico crónico en pacientes con endometriosis. Revisión bibliográfica.

In: Revista de la Sociedad Española del Dolor · 2026 · doi:10.20986/resed.2026.4228/2025 · W7144220563
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This literature review identifies risk factors associated with the development of chronic pelvic pain in patients diagnosed with endometriosis.

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This narrative review compiles known and proposed risk factors in women diagnosed with endometriosis that are associated with the later development of chronic pelvic pain, discussing high-level mechanisms such as nerve infiltration/damage, inflammation, and related pain pathways. It outlines the multifactorial nature of endometriosis and its clinical symptom spectrum (including dysmenorrhea, chronic pelvic pain, dyspareunia, dyschezia, dysuria, and infertility), and it mentions both medical and surgical approaches for pain treatment in general. A key limitation is that, as a narrative review, it does not provide a structured, systematic synthesis of risk factors or specify the strength of evidence across included studies. This paper is centrally about endometriosis — it focuses on risk factors for developing chronic pelvic pain in patients with endometriosis.

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Abstract

This narrative review is presented to elucidate the risk factors present in patients diagnosed with endometriosis that lead to the development of chronic pelvic pain. The ultimate goal is to establish more effective and personalized therapies, avoiding the consequences of persistent pain. Endometriosis is a chronic, benign gynecological disease characterized by the growth of endometrial-like tissue outside the uterine cavity. This ectopic tissue acts like the eutopic endometrium: it thickens, breaks down, and bleeds during the menstrual cycle. Despite being benign, endometriosis infiltrates tissues and causes an inflammatory reaction in the areas where it is implanted. Both are responsible for the clinical symptoms, including dysmenorrhea, chronic pelvic pain, dyspareunia, dyschezia, dysuria, and infertility. Endometriosis is a multifactorial disease with no known cause. Several mechanisms may contribute to pain, including direct compression or infiltration of nerves, inflammation, and nerve damage or dysfunction. Treatment of pain associated with endometriosis can be medical or surgical. A holistic understanding of the risk factors for the development of chronic pelvic pain in patients with endometriosis is essential. This understanding, along with a multidisciplinary approach, is key to proper diagnosis and treatment, with the ultimate goal of improving patients’ quality of life.
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Abstract This narrative review is presented to elucidate the risk factors present in patients diagnosed with endometriosis that lead to the development of chronic pelvic pain. The ultimate goal is to establish more effective and personalized therapies, avoiding the consequences of persistent pain. Endometriosis is a chronic, benign gynecological disease characterized by the growth of endometrial-like tissue outside the uterine cavity. This ectopic tissue acts like the eutopic endometrium: it thickens, breaks down, and bleeds during the menstrual cycle. Despite being benign, endometriosis infiltrates tissues and causes an inflammatory reaction in the areas where it is implanted. Both are responsible for the clinical symptoms, including dysmenorrhea, chronic pelvic pain, dyspareunia, dyschezia, dysuria, and infertility. Endometriosis is a multifactorial disease with no known cause. Several mechanisms may contribute to pain, including direct compression or infiltration of nerves, inflammation, and nerve damage or dysfunction. Treatment of pain associated with endometriosis can be medical or surgical. A holistic understanding of the risk factors for the development of chronic pelvic pain in patients with endometriosis is essential. This understanding, along with a multidisciplinary approach, is key to proper diagnosis and treatment, with the ultimate goal of improving patients’ quality of life.References 1. Cousins FL, McKinnon BD, Mortlock S, Fitzgerald HC, Zhang C, Montgomery GW, et al. New concepts on the etiology of endometriosis. J Obstet Gynaecol Res. 2023;49(4):1090-105. 2. Yoshino O, et al. Possible pathophysiology of endometriosis-associated pain. J Obstet Gynaecol Res. 2018;44(10):1912-20. 3. Li R, et al. Prevalence and risk factors of dysmenorrhea among female students. J Pediatr Adolesc Gynecol. 2020;33(3):258-64. 4. Karp BI, Stratton P. 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