Serum anti-Mullerian hormone, prolactin and estradiol concentrations in infertile women with endometriosis

Н. Ю. Педаченко, Panagiotis Anagnostis, Taras Shemelko, T. L. Shemelko, Roksana Tukhtarian, Lina Alabbas
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2020 · vol. 37(2) , pp. 162–165 · doi:10.1080/09513590.2020.1855634 · PMID:33274686 · W3108848720
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Infertile women with endometriosis had higher prolactin and lower AMH levels than those without, with ovarian endometriomas correlating with the highest prolactin and lowest AMH.

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Abstract

Objective Endometriosis is a benign gynecological disease, which significantly impairs fertility. However, the contribution of specific hormonal parameters to the proper diagnosis of endometriosis in infertility states has not been adequately determined. The aim of this study was to compare ant-Mullerian hormone (AMH), prolactin and estradiol concentrations between infertile women with and without endometriosis, as well as to estimate the effect of endometrioid heterotopia on ovarian reserve.Methods In this cross-sectional study, mean baseline serum AMH, prolactin and estradiol levels were assessed in infertile women with and without endometriosis. Descriptive statistics are presented in the form of arithmetic mean ± standard deviation (SD). The comparison of indicators was performed by using parametric (t-test) and non-parametric criteria (Mann–Whitney).Results Seventy-two infertile women with endometriosis (group A; mean age: 32 ± 4.3 years) and 77 infertile women without endometriosis (group B; mean age: 32.4 ± 3.7 years) were studied. Mean baseline prolactin concentrations were higher in group A (16.9 ± 5.7 ng/mL) compared with group B (15 ± 4.3 ng/mL; p = .023), whereas mean AMH concentrations were lower (2.8 ± 1.9 ng/mL and 3.5 ± 1.8 ng/mL, respectively; p = .018). The highest prolactin and the lowest AMH concentrations were found in women with ovarian endometriomas than in those with deep infiltrative endometriosis and adenomyosis. There was no difference in estradiol levels between groups.Conclusions Infertile women with endometriosis demonstrated higher prolactin and lower AMH concentrations, compared with infertile women without endometriosis. The highest prolactin and the lowest AMH concentrations were observed in patients with ovarian endometriomas.

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Condition tags

endometriosisadenomyosisinfertility

MeSH descriptors

Anti-Mullerian Hormone Endometriosis Estradiol Infertility, Female Prolactin Adult Anti-Mullerian Hormone Cross-Sectional Studies Endometriosis Endometriosis Estradiol Female Humans Infertility, Female Infertility, Female Prolactin

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