The Role of Prolactin– and Endometriosis-Associated Infertility

Hongbo Wang, Wang H, Gorpudolo N, Nowiah Gorpudolo, Barry Behr, Behr B
Obstetrical & gynecological survey · 2009 · vol. 64(8) , pp. 542–547 · doi:10.1097/ogx.0b013e3181ab5479 · PMID:19624865 · W2060082358
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This review examines the relationship between prolactin levels, prolactin receptors, and various factors in endometriosis-associated infertility based on existing literature.

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This review examines the current understanding of the relationship between prolactin and infertility in patients with endometriosis. The authors analyze existing literature regarding serum prolactin levels, prolactin receptors in ectopic tissues, and hormonal concentrations in peritoneal fluid and during the luteal phase. While the exact mechanisms linking hyperprolactinemia to endometriosis-associated infertility remain unclear, the report synthesizes data on basal prolactin levels following therapy and nocturnal serum fluctuations. This paper is centrally about endometriosis — specifically investigating how prolactin dynamics contribute to infertility in this population.

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Abstract

UNLABELLED: This review will address the current understanding of the relationship between prolactin (PRL) and endometriosis-associated infertility. Although the exact mechanisms of action of hyperprolactinemia in patients with endometriosis-associated infertility have not been clearly established, this report reviews results from relevant studies in the literature. These include serum PRL levels in endometriosis-associated infertility, PRL receptors in ectopic endometriotic tissues, basal PRL levels after TSH and Danazol (isoxazolic derivative of the synthetic steroid 5alpha-ethinyl-testosterone) therapy, peritoneal fluid and nocturnal serum PRL levels in endometriosis, infertility, and luteal phase PRL concentrations in patients with endometriosis. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES: After completion of this article, the reader should be able to explain the relationship between prolactin- and endometriosis-associated infertility, relate endometriosis with infertility, and summarize two ways in which prolactin and endometriosis may be linked in the pathophysiology of infertility.
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The Role of Prolactin– and Endometriosis-Associated Infertility - Hongbo Wang - Nowiah Gorpudolo - Barry Behr This review will address the current understanding of the relationship between prolactin (PRL) and endometriosis-associated infertility. Although the exact mechanisms of action of hyperprolactinemia in patients with endometriosis-associated infertility have not been clearly established, this report reviews results from relevant studies in the literature. These include serum PRL levels in endometriosis-associated infertility, PRL receptors in ectopic endometriotic tissues, basal PRL levels after TSH and Danazol (isoxazolic derivative of the synthetic steroid 5α-ethinyl-testosterone) therapy, peritoneal fluid and nocturnal serum PRL levels in endometriosis, infertility, and luteal phase PRL concentrations in patients with endometriosis. Target Audience: Obstetricians & Gynecologists, Family Physicians Learning Objectives: After completion of this article, the reader should be able to explain the relationship between prolactin- and endometriosis-associated infertility, relate endometriosis with infertility, and summarize two ways in which prolactin and endometriosis may be linked in the pathophysiology of infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Prolactin Danazol Danazol Endometriosis Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Prolactin Prolactin Prolactin Receptors, Prolactin Receptors, Prolactin

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

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