[Prolactin secretion in patients with endometriosis and its relationship to luteal phase defect and infertility].

He YE, Y E He, Yonglan He
Zhonghua fu chan ke za zhi · 1993 · vol. 28(1) , pp. 14–7, 59 · PMID:8504702 · W2418028400
article OA: closed CC0 ⤵ 6 in-corpus citations
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This study found that higher prolactin levels in endometriosis patients correlated with infertility and delayed endometrial maturation, suggesting hyperprolactinemia may cause luteal phase defects.

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Abstract

UNLABELLED: Serum prolactin (PRL) levels and PRL response to TRH stimulation were studied in 49 patients with endometriosis (EM) during mid-luteal phase. Eight cases with other gyn-diseases and 14 normal fertile women served as controls. Their luteal function were also estimated by three serum progesterone(P) measurements during the luteal phase and endometrial dating in the late luteal phase. RESULTS: The incidence of hyperprolactinemia in EM group (32.7%), and in EM with primary infertility group (61.5%) was significantly higher than that in normal controls (7.1%) (P < 0.05). However, the PRL secretory capacity was not positively correlated to the severity of EM. There was no difference in serum P levels between EM and two control groups. But delayed endometrial maturation was shown in 6 EM infertile cases suggesting luteal phase defect, an incidence of 27.3% (6/22) in EM group or 42.9% (6/14) in EM infertile group. Five out of the six were hyperprolactinemic and had no other identified causes of infertility. These data implied that hyperprolactinemia may impair the luteal function causing infertility in EM patients.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Prolactin Uterine Neoplasms Adult Endometriosis Endometriosis Female Humans Hyperprolactinemia Hyperprolactinemia Infertility, Female Infertility, Female Luteal Phase Luteal Phase Progesterone Progesterone Prolactin Prolactin Thyrotropin-Releasing Hormone

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