The role of prolactin аnd dopamine in the pathogenesis of endometriosis

Е. В. Суслова, Maria I. Yarmolinskaya, Vladimir Vsevolodovich Potin
In: Journal of obstetrics and women's diseases · 2016 · vol. 65(3) , pp. 52–63 · doi:10.17816/jowd65352-63 · W2498784818
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review analyzes literature on prolactin and dopamine's role in endometriosis pathogenesis and the potential therapeutic use of dopamine agonists.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews the roles of prolactin and dopamine in reproductive physiology and explains how dysregulation of the prolactin axis could contribute to endometriosis pathogenesis, drawing on mechanistic literature about prolactin secretion, dopamine D1/D2 receptor effects, and factors that stimulate or inhibit prolactin. It describes dopamine’s inhibitory control of tuberoinfundibular prolactin release, outlines prolactin biology and receptor distribution, and summarizes how hyperprolactinemia can disrupt luteal function through impaired progesterone production and inhibited GnRH signaling. The authors explicitly note that endometriosis-related prolactin elevation may be multifactorial—linked to hyperestrogenemia, immune activation by ectopic endometrial cells, and pain-associated central neurotransmitter changes—while also referencing that luteal-phase endometrium and potentially endometriotic lesions may secrete prolactin. This paper is centrally about endometriosis — it focuses on prolactin and dopamine pathways as contributors to endometriosis pathogenesis, including proposed mechanisms involving luteal-phase disruption.

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Abstract

Background: to consider the modern ideas of a role of prolactin and dopamine in a pathogenesis of the endometriosis and possibility to apply of agonists of dopamine in disease,s therapy. Materials: literary data of foreign and native authors from 1972 for 2015. Methods: systematic analysis and synthesis of publications. Conclusion: Carrying out further researches of a role of prolactin and dopamine in a pathogenesis of endometriosis and multicenter supervision is necessary for confirmation of safety and effectiveness of therapy by dopamine agonists.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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