Immunohistochemical analysis of the role of angiogenic status in the vasculature of peritoneal endometriosis

Matsuzaki S, S Matsuzaki, Sachiko Matsuzaki, Michel Canis, M Canis, T Murakami, Murakami T, Takashi Murakami, P Dechelotte, Pierre Déchelotte, Dechelotte P, M A Bruhat, Bruhat MA, M Bruhat, Okamura K, Kunihiro Okamura, K. Okamura
Fertility and sterility · 2001 · vol. 76(4) , pp. 712–716 · doi:10.1016/s0015-0282(01)02003-9 · PMID:11591403 · W2088782991
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This study used immunohistochemistry to investigate the role of angiogenic factors in the blood vessels of peritoneal endometriosis.

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Abstract

ObjectiveTo investigate the angiogenic status of the vasculature in peritoneal endometriosis based on macroscopic appearance.DesignProspective study.SettingUniversity hospital.Patient(s)Patients with peritoneal endometriosis.Intervention(s)During laparoscopy, 25 samples of predominantly red peritoneal lesions and 27 samples of predominantly black peritoneal lesions were collected from a total of 31 patients with endometriosis. Eutopic endometrium from 25 patients with endometriosis was collected by curettage during laparoscopy or just after surgery.Main outcome measure(s)A proliferating endothelial cell index (PCI) was determined by calculating the percentage of microvessels that contained proliferating endothelial cells. A vessel maturation index (VMI) was determined by calculating the percentage of microvessels showing colocalization of CD34- and alpha-SMA-positive staining.Result(s)Peritoneal endometriotic tissues had extremely low or null PCI. The VMI of red peritoneal lesions was significantly lower than that of black ones. Vessel maturation index of red lesions was higher that that of proliferative eutopic endometrium and similar to that of secretory eutopic endometrium.Conclusion(s)Compared with the case of black peritoneal lesions, red lesions had a much higher fraction of immature vessels.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neovascularization, Pathologic Peritoneal Diseases Actins Actins Adult Antigens, CD34 Antigens, CD34 Blood Vessels Blood Vessels Blood Vessels Cell Division Endometriosis Endothelium, Vascular Endothelium, Vascular Female Humans Immunohistochemistry Muscle, Smooth, Vascular Muscle, Smooth, Vascular

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Cited by (34)

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