2-Methoxyestradiol in the Pathophysiology of Endometriosis: Focus on Angiogenesis and Therapeutic Potential

Francisco Machado-Linde, Francisco Machado‐Linde, Pablo Pelegrin, Pablo Pelegrı́n, María Luisa Sánchez-Ferrer, Maria L Sanchez-Ferrer, Josefa Leon, Josefa León, Pedro Cascales, Juan J Parrilla, Juan José Parrilla
Reproductive sciences (Thousand Oaks, Calif.) · 2012 · vol. 19(10) , pp. 1018–1029 · doi:10.1177/1933719112446080 · PMID:22875846 · W2009562357
review OA: closed CC0 ⤵ 10 in-corpus citations
Limited metadata. Only one source feed has indexed this record so far — no abstract, full text, or open-access copy is available through Endo Lab. The publisher's page (linked below) is the canonical location for the actual content. If you have institutional access, use "Find at my library".
View at publisher → View on OpenAlex View on PubMed
⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

This review summarizes current knowledge of endometriosis pathophysiology, focusing on the balance between local 2-methoxyestradiol production and angiogenesis, and its therapeutic potential.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This paper is a review of endometriosis pathophysiology, focusing on how local hypoxia and the hypoxia-inducible factor–vascular endothelial growth factor pathway may shift the proangiogenic/antiangiogenic balance to support development of endometriotic implants. It emphasizes 2-methoxyestradiol, an estradiol metabolite with antiangiogenic activity, and summarizes evidence that endometriosis involves altered estradiol homeostasis, which could affect local 2-methoxyestradiol production and angiogenesis. The review highlights 2-methoxyestradiol as a therapeutic candidate in light of mechanistic links between antiangiogenic signaling and lesion growth, while acknowledging the limitation inherent to a narrative summary of “current knowledge.” This paper is centrally about endometriosis — it focuses specifically on 2-methoxyestradiol’s relationship to angiogenesis and its therapeutic potential in endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Estradiol Neovascularization, Pathologic Neovascularization, Pathologic 2-Methoxyestradiol Animals Apoptosis Apoptosis Cell Proliferation Cell Proliferation Endometriosis Estradiol Estradiol Estradiol Female Humans Mice Neovascularization, Pathologic Rats

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (10)

Source provenance

europepmc
last seen: 2026-06-12T06:13:51.797165+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:16:04.919516+00:00
License: CC0 · commercial use OK