Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis

Jouko Halme, Halme J, J Halme, S Becker, Susanne Becker, Becker S, Wing R, Richard M. Wing, R Wing
American journal of obstetrics and gynecology · 1984 · vol. 148(1) , pp. 85–90 · doi:10.1016/s0002-9378(84)80037-x · PMID:6691385 · W2007654790
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This study investigated the cyclic activation of peritoneal macrophages in patients with endometriosis and found it to be accentuated.

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Abstract

Peritoneal fluid was collected from 107 women undergoing laparoscopic sterilization or diagnostic laparoscopy for evaluation of infertility. Cells consisting mainly of macrophages were separated and subjected to sophisticated flow fluorocytometric analysis. In this way more detailed information was obtained about activational characteristics of the pelvic macrophage population during the menstrual cycle. In normal women the macrophages, as compared to peripheral monocytes, showed evidence of elevated baseline activation, and a gradual increase in several markers occurred during the menstrual cycle. Cells increased in size, lost their ability to stain for myeloperoxidase, and increased in activity of both endoenzymes and ectoenzymes. These results suggest that female peritoneal macrophages are continuously responding to stimuli. The macrophage irritation was much more pronounced in women with mild endometriosis. This accentuated cyclic activation may represent an inflammatory response to bleeding from ectopic implants or retrograde menstruation or may be a consequence of some defect in the cell-mediated immune response in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Macrophage Activation Menstruation Uterine Neoplasms Ascitic Fluid Cell Separation Endometriosis Female Flow Cytometry Humans Macrophages Macrophages Macrophages Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Cited by (50)

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