Mesothelin as a diagnostic biomarker in endometriosis: A cross-sectional study

Kiecka K, Kamil Kiecka, Aleksandra Zygula, Aleksandra Zyguła, Zygula A, Sankiewicz A, Anna Sankiewicz, Kuzmicki M, Mariusz Kuźmicki, Mariusz Kuzmicki, Lawicki S, Slawomir Lawicki, Sławomir Ławicki, Ciebiera M, Michal Ciebiera, Michał Ciebiera, Tadeusz Issat, Blaszczyk J, Jan Blaszczyk, Jan Błaszczyk, Krzysztof Cendrowski, Cendrowski K, Gorodkiewicz E, Ewa Gorodkiewicz, Piotr Laudański, Piotr Laudanski
Advances in medical sciences · 2025 · vol. 71(1) , pp. 1–8 · doi:10.1016/j.advms.2025.11.002 · PMID:41320152 · W4416796078
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This cross-sectional study investigated mesothelin as a diagnostic biomarker for endometriosis by analyzing its levels in patient samples.

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Abstract

PURPOSE: Endometriosis is a prevalent gynecological condition often requiring invasive procedures for diagnosis. This study aimed to assess mesothelin (MSLN) as a potential non-invasive biomarker by analyzing its levels in peritoneal fluid (PF) and plasma. MATERIALS/METHODS: In a multicenter cross-sectional study, MSLN concentrations were measured using Surface Plasmon Resonance imaging (SPRi) biosensors in samples from women undergoing laparoscopy for pelvic pain or infertility. RESULTS: Significantly higher MSLN levels were observed in the PF of patients with endometriosis compared to controls (mean concentrations: 10.24 vs. 9.39 ​ng/mL, p ​= ​0.038). The elevation was particularly notable in patients with stage I and II endometriosis compared to the control group (mean concentrations: 10.83 vs. 9.39 ​ng/mL, p ​= ​0.049). No significant differences were observed in plasma. CONCLUSIONS: Mesothelin in PF may be considered as a potential biomarker for endometriosis, especially in its early stages. Further studies are needed to confirm its diagnostic value.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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