Cytokine and growth factor profile in endometriosis: a multiplex analysis of peritoneal fluid to assess diagnostic utility

Jaiswal U, Urja Jaiswal, Raj Kumar Yadav, Muzaffer Ahmed Bhat, Bhat MA, Alka Kriplani, Kriplani A, Roy KK, Kallol Kumar Roy, Netam RK, Ritesh Kumar Netam, Ritesh Netam
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2020 · vol. 36(8) , pp. 718–722 · doi:10.1080/09513590.2020.1712695 · PMID:31958023 · W3002932856
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Multiplex analysis of peritoneal fluid revealed lower FGF2 and CSF3 levels in women with endometriosis, and higher CCL2 and IL1RN in moderate-severe disease, suggesting diagnostic potential.

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Abstract

We aimed to assay cytokines and growth factors in peritoneal fluid samples from women with and without endometriosis to understand the inflammatory milieu, and assess their potential diagnostic utility. This cross-sectional study conducted at a tertiary care hospital included 54 women, aged 20–45 years, with regular menstrual history and undergoing diagnostic/therapeutic laparoscopy for infertility and/or pain. Peritoneal fluid samples were collected after insertion of trocar & laparoscope but prior to other surgical intervention. A multiplex immunoassay of 27 cytokines and growth factors was performed. The concentration of FGF2 and CSF3 were significantly lower in women with endometriosis than without endometriosis (p = .043 and .003, respectively). The levels of CCL2 and IL1RN were significantly higher in moderate-severe than in minimal-mild endometriosis (p = .038 and .043, respectively). Phase-specific comparison revealed that in proliferative phase, the levels of CSF2 and CSF3 were lower in women with endometriosis than without the disease (p = .047 and .013, respectively). The ROC curve analysis provided a cutoff value 0.78 and 0.76 for FGF2 and CSF3, respectively. Cytokines and growth factors such as FGF2, CSF3, CSF2, CCL2 and IL1RN seem to contribute to the pathogenesis of endometriosis and may have a potential utility for the diagnosis of endometriosis.

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Condition tags

endometriosischronic_pelvic_paininfertility

MeSH descriptors

Ascitic Fluid Cytokines Endometriosis Intercellular Signaling Peptides and Proteins Peritoneal Diseases Adult Ascitic Fluid Ascitic Fluid Case-Control Studies Cross-Sectional Studies Cytokines Cytokines Endometriosis Endometriosis Endometriosis Endometriosis Female Gynecologic Surgical Procedures Humans Immunoassay

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