Distinct peritoneal fluid ghrelin and leptin in infertile women with endometriosis and their correlation with interleukin-6 and vascular endothelial growth factor

Neha Rathore, Alka Kriplani, Raj Kumar Yadav, Urja Jaiswal, Ritesh Netam
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2014 · vol. 30(9) , pp. 671–675 · doi:10.3109/09513590.2014.920318 · PMID:24845415 · W2088541926
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This study found higher peritoneal fluid leptin and lower ghrelin in women with endometriosis and infertility, with leptin positively correlated to IL-6.

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Abstract

OBJECTIVE: The objective of the present study was to evaluate the levels of leptin, ghrelin, interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in peritoneal fluid in patients with endometriosis and infertility, and study their correlation. DESIGN AND SETTING: This cross-sectional study included women undergoing diagnostic and/or therapeutic laparoscopy for endometriosis with chief complaint of infertility and/or pain at a tertiary care hospital. Based upon laparoscopic and histopathological findings, patients were categorized as with endometriosis and no endometriosis. Of the 50 patients with infertility (age 23-41 years), 19 had endometriosis while 31 had no endometriosis. The markers were assessed using ELISA kits. RESULTS: The median levels of leptin in patients with endometriosis (10.20 ng/mL) were higher (p = 0.04) and median levels of ghrelin in patients with endometriosis (150.4 pg/mL) were lower (p = 0.037) versus patients with no endometriosis (5.07 ng/mL and 229.6 pg/mL, respectively). The median levels of IL-6 and VEGF in patients with endometriosis were not different between the groups. The correlation analyses showed that leptin levels and IL-6 were positively correlated (p = 0.0001). CONCLUSIONS: The results suggest that ghrelin and leptin might play a key role in pathophysiology of endometriosis, and leptin is associated with inflammation in endometriosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Ghrelin Infertility, Female Interleukin-6 Leptin Vascular Endothelial Growth Factor A Adult Ascitic Fluid Ascitic Fluid Cross-Sectional Studies Endometriosis Endometriosis Female Ghrelin Humans Infertility, Female Infertility, Female Interleukin-6 Leptin Vascular Endothelial Growth Factor A

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