Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis

Neena Malhotra, Debjyoti Karmakar, Vishwas Tripathi, Kalpana Luthra, Sunesh Kumar
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2011 · vol. 28(3) , pp. 224–227 · doi:10.3109/09513590.2011.593664 · PMID:21848410 · W2080661074
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This study found elevated leptin and IL-8 levels in the peritoneal fluid of women with endometriosis, correlating with disease stage and type, but not with infertility or pain.

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Abstract

UNLABELLED: Pelvic endometriosis is a chronic inflammatory disease with an immunological background. Yet there is paucity of contemporary research exploring both the angiogenic cytokines, leptin and IL-8 for a possible role in its pathophysiology. OBJECTIVE: To compare levels of both leptin and IL-8 in peritoneal fluid (PF) in women with endometriosis vs. fertile controls and correlate with disease stage, type and symptoms. MATERIALS AND METHODS: PF from 58 women with endometriosis and 28 women undergoing tubal ligation was collected at laparoscopy and leptin and IL-8 levels were measured using ELISA. Results showed significantly higher levels of both cytokines in women with endometriosis. Significantly higher leptin and IL-8 levels were demonstrated in patients with early peritoneal (ASRM stage I and II) and advancing disease (ASRM stage III and IV), respectively. Levels of leptin/IL-8 were significantly lower in patients with endometrioma (4.8 ng/mL/32 pg/mL) vs. implants (13.0 ng/mL/68 pg/mL). There was no correlation of infertility or chronic pelvic pain with these levels. CONCLUSION: Both leptin and IL-8 levels are raised in PF of women with endometriosis reflecting inflammation and dysregulated immunomodulation. Higher levels of leptin were seen in early stages; IL-8 seems to stimulate the disease in a dose-dependent manner.

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Condition tags

endometriosischronic_pelvic_painendometriomainfertility

MeSH descriptors

Ascitic Fluid Endometriosis Endometriosis Interleukin-8 Leptin Adult Ascitic Fluid Case-Control Studies Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Infertility, Female Interleukin-8 Leptin Ovarian Diseases Ovarian Diseases Ovarian Diseases

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Cited by (39)

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