Endometriosis, Angiogenesis and Tissue Factor

Graciela Krikun
Scientifica · 2012 · vol. 2012 , pp. 1–10 · doi:10.6064/2012/306830 · PMID:24278684 · PMC3820463 · W2163986345
review OA: gold CC0 ⤵ 18 in-corpus citations
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This review examines altered tissue factor expression in endometriosis and presents findings from a novel immunoconjugate that eradicated endometrial lesions in a mouse model without impacting fertility.

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Abstract

Tissue factor (TF), is a cellular receptor that binds the factor VII/VIIa to initiate the blood coagulation cascade. In addition to its role as the initiator of the hemostatic cascade, TF is known to be involved in angiogenesis via intracellular signaling that utilizes the protease activated receptor-2 (PAR-2). We now review the physiologic expression of TF in the endometrium and its altered expression in multiple cell types derived from eutopic and ectopic endometrium from women with endometriosis compared with normal endometrium. Our findings suggest that TF might be an ideal target for therapeutic intervention in endometriosis. We have employed a novel immunoconjugate molecule known as Icon and were able to eradicate endometrial lesions in a mouse model of endometriosis without affecting fertility. These findings have major implications for potential treatment in humans.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (18)

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License: CC0 · commercial use OK