Anomalies in the inflammatory response in endometriosis and possible consequences: a review.
article
OA: closed
CC0
⤵ 36 in-corpus citations
AI-generated summary
This review examines pro-inflammatory cellular and immunological changes observed in endometriosis patients, detailing their impact on angiogenesis, apoptosis, extracellular matrix remodeling, hormonal production, and fertility.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Defined by the presence of endometrial-like cells outside the uterus, endometriosis is one of the most diagnosed gynecological disorders, affecting 5 to 10 % of reproductive age women, but the true incidence is unknown. Endometriosis is a major cause of pelvic pain, dysmenorrhea, dyspareunia, infertility and menstrual irregularities, but there is no clear correlation between the symptoms and the extent of the disease. Despite decades of intensive investigations, little is known about the pathogenesis of endometriosis. The disease is often associated with chronic pelvic inflammation. Abnormal levels of immune cells such macrophages, dendritic and natural killer cells were found in the peritoneal cavity of patients. However these cells seem to be unable to detect and eliminate ectopic endometrial cells. Several studies showed that peritoneal immune cells are dysfunctional and may rather contribute to endometriosis development. A review of relevant clinical and scientific studies was carried out. This review sheds light on cellular and immunological pro-inflammatory changes which were observed in patients with endometriosis, their impact on angiogenesis, apoptosis, extracellular matrix remodeling and hormonal production and consequences on fertility.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
Cited by (36)
- Potential shared pathogenic mechanisms between endometriosis and inflammatory bowel disease indicate a strong initial effect of immune factors 2024
- The Extracellular Vesicle-Macrophage Regulatory Axis: A Novel Pathogenesis for Endometriosis 2023
- Surgical management of endometriosis to optimize fertility 2023
- Epigenetic regulation and T-cell responses in endometriosis - something other than autoimmunity 2022
- Macrophages in endometriosis 2021
- Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study 2020
- Estrogen-regulated CD200 inhibits macrophage phagocytosis in endometriosis 2020
- Anti-angiogenesis effect and mechanism study of Huangzhi Neiyi capsule in a rat endometriosis model 2020
- Increased risk of endometriosis in patients with endometritis — a nationwide cohort study involving 84,150 individuals 2020
- Fibrinogen alpha chain promotes the migration and invasion of human endometrial stromal cells in endometriosis through focal adhesion kinase/protein kinase B/matrix metallopeptidase 2 pathway† 2020
- Elevated urine histone 4 levels in women with ovarian endometriosis revealed by discovery and parallel reaction monitoring proteomics 2019
- Cardiometabolic Risk Factors and Benign Gynecologic Disorders 2019
- MDSCs drive the process of endometriosis by enhancing angiogenesis and are a new potential therapeutic target 2018
- “What do we know about regulatory T cells and endometriosis? A systematic review” 2017
- Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why 2017
- An Update on Pathophysiology and Medical Management of Endometriosis 2016
- Increased Risk of Endometriosis in Patients With Lower Genital Tract Infection 2016
- Laparoscopic Surgery: A New Technique to Induce Endometriosis in a Mouse Model 2016
- Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted? 2015
- Soluble ST2 and IL-33: Potential markers of endometriosis in the Tunisian population 2015
- Le facteur inhibant la migration des macrophages, une cytokine clé dans l’endométriose 2015
- Pain related genes in endometriosis: A meta-analysis 2015
- The development of endometriosis in a murine model is dependent on the presence of dendritic cells 2014
- Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype 2014
- Guizhi Fuling capsule, an ancient Chinese formula, attenuates endometriosis in rats via induction of apoptosis 2014
- Macrophage Migration Inhibitory Factor Is Involved in Ectopic Endometrial Tissue Growth and Peritoneal-Endometrial Tissue Interaction In Vivo: A Plausible Link to Endometriosis Development 2014
- Blood soluble interleukin 1 receptor accessory protein levels are consistently low throughout the menstrual cycle of women with endometriosis 2014
- The role of Lipoxin A4 in endometrial biology and endometriosis 2013
- Increased Expression of Pattern Recognition Receptors and Nitric Oxide Synthase in Patients with Endometriosis 2013
- Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. 2013
- Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis 2013
- Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation (Review) 2013
- Endometriosis: causas, histopatogenia y epidemiología en México y el mundo 2013
- Possible effects of endometriosis-related immune events on reproductive function 2013
- Macrophages: Are They Involved in Endometriosis, Abortion and Preeclampsia and How? 2013
- Endometriosis, Angiogenesis and Tissue Factor 2012
Source provenance
- europepmc
- last seen: 2026-06-24T06:10:11.469335+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:16:17.081435+00:00
License: CC0
· commercial use OK