Estrogen-regulated CD200 inhibits macrophage phagocytosis in endometriosis
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Estrogen upregulates CD200 on endometrial cells, which then suppresses macrophage phagocytic activity, contributing to endometriosis development.
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References (57)
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Cited by (15)
- Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies 2025
- Immune Checkpoints in Endometriosis—A New Insight in the Pathogenesis 2024
- Immunological aspects of endometriosis: pathophysiological mechanisms, diagnosis, autoimmunity, targeted therapy and modulation 2024
- Efferocytosis and infertility: Implications for diagnosis and therapy 2024
- Immune and endocrine regulation in endometriosis: what we know 2023
- Peritoneal immune microenvironment of endometriosis: Role and therapeutic perspectives 2023
- The Extracellular Vesicle–Macrophage Regulatory Axis: A Novel Pathogenesis for Endometriosis 2023
- Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages 2023
- Baicalein Relieves Ferroptosis-Mediated Phagocytosis Inhibition of Macrophages in Ovarian Endometriosis 2022
- Circulating CD200 is increased in the secretory phase of women with endometriosis as is endometrial mRNA, and endometrial stromal cell CD200R1 is increased in spite of reduced mRNA 2022
- SCM-198 Alleviates Endometriosis by Suppressing Estrogen-ERα mediated Differentiation and Function of CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells 2022
- Integrating endometrial proteomic and single cell transcriptomic pipelines reveals distinct menstrual cycle and endometriosis-associated molecular profiles 2022
- Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies† 2021
- The Role of Peritoneal Macrophages in Endometriosis 2021
- CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis 2020
Source provenance
- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:22:17.025735+00:00
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