Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis

Pei‐Chin Chuang, Pei-Chin Chuang, Meng-Hsing Wu, Meng‐Hsing Wu, Yutaka Shoji, Shaw-Jenq Tsai, Shaw‐Jenq Tsai
The Journal of Pathology · 2009 · vol. 219(2) , pp. 232–241 · doi:10.1002/path.2588 · PMID:19606481 · W2074112194
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Peritoneal macrophages from women with endometriosis exhibit reduced phagocytic ability due to lower levels of the scavenger receptor CD36.

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Abstract

Endometriosis, defined as the growth of endometrial tissues outside of the uterine cavity, is a severe and complex disease affecting more than 10% of women. The aetiology of endometriosis is unclear but immune dysfunction might be an important factor for its development. The natural function of the immune system is to detect and destroy aberrant or abnormal cells. Failure of the immune system to eradicate these aberrant cells often results in disease pathogenesis. We report here that the phagocytic ability of macrophages is reduced in peritoneal macrophages isolated from women with endometriosis. In-depth investigation revealed that the level of CD36, a class B scavenger receptor, in peritoneal macrophages derived from women with endometriosis was lower than that in normal macrophages. Blockage of CD36 function by neutralized antibody or knocking down CD36 using siRNA impaired the phagocytic ability of normal macrophages. In contrast, forced expression of CD36 in macrophages isolated from women with endometriosis restored phagocytic ability. Taken together, we identified that the scavenger receptor CD36 is reduced in the peritoneal macrophages of women with endometriosis, which leads to a decrease of the phagocytic ability of macrophages. These findings revealed a potential mechanism of immune dysfunction during endometriosis development.

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Condition tags

endometriosis

MeSH descriptors

CD36 Antigens Down-Regulation Endometriosis Macrophages, Peritoneal Phagocytosis Adolescent Adult CD36 Antigens CD36 Antigens CD36 Antigens Down-Regulation Endometriosis Female Gene Knockdown Techniques Humans Macrophages, Peritoneal Middle Aged Phagocytosis Reverse Transcriptase Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction

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