Modern Ideas on the Role of Macrophages and Neutrophils in the Development of Endometriosis

L.I. Martynova, Aleksey M. Chaulin, Vladimir Vankov, Julia Grigoryeva
In: Bulletin of Science and Practice · 2023 · pp. 159–174 · doi:10.33619/2414-2948/94/19 · W4386735094
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review summarizes current knowledge regarding the involvement of macrophages and neutrophils in the pathogenesis and progression of endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 · read from full text ⓘ

This review article examines current ideas about the role of immune-inflammatory mechanisms in the development and progression of endometriosis, focusing specifically on macrophages and neutrophils. The authors describe why improved understanding of endometriosis pathogenesis is needed, and frame their synthesis as supporting future discovery of laboratory biomarkers for early diagnosis and therapeutic targets. A key limitation explicitly noted is that diagnosis and treatment remain imperfect, attributed to insufficient knowledge of the disease pathogenesis, which motivates the review rather than providing new experimental results. This paper is centrally about endometriosis — it summarizes macrophage and neutrophil roles in endometriosis pathogenesis.

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Abstract

Endometriosis is one of the most common gynecological diseases. Methods of diagnosis and treatment of endometriosis are imperfect, which is probably due to insufficient knowledge of the pathogenesis of this disease. Recently, research efforts have focused on the study of immunoinflammatory mechanisms in the development and progression of endometriosis. Understanding the pathogenetic mechanisms of endometriosis is important for the discovery of new laboratory biomarkers for early diagnosis and new targets for therapeutic effects. This article summarizes information on the role of some of the main cells of the immune system (macrophages and neutrophils) in the pathogenesis of endometriosis.
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СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О РОЛИ МАКРОФАГОВ И НЕЙТРОФИЛОВ В РАЗВИТИИ ЭНДОМЕТРИОЗА МАРТЫНОВА Л.Б.1, ЧАУЛИН А.М.*2,3, ВАНЬКОВ В.А.2, ГРИГОРЬЕВА Ю.В.2 1 Самарская городская больница №6, г. Самара, Россия 2Самарский государственный медицинский университет, г. Самара, Россия 3Самарский областной клинический кардиологический диспансер Тип: статья в журнале - обзорная статья Язык: русский Эндометриоз является одним из распространенных гинекологических заболеваний. Методы диагностики и лечения эндометриоза несовершенны, что, вероятно, обусловлено, недостаточной изученностью патогенеза данного заболевания. В последнее время усилия исследований сосредоточены на изучении иммуновоспалительных механизмов в развитии и прогрессировании эндометриоза. Понимание патогенетических механизмов эндометриоза важно для открытия новых лабораторных биомаркеров для ранней диагностики и новых мишеней для терапевтического воздействия. В данной статье суммируются сведения о роли одних из основных клеток иммунной системы (макрофагов и нейтрофилов) в патогенезе эндометриоза. БИБЛИОМЕТРИЧЕСКИЕ ПОКАЗАТЕЛИ: Входит в РИНЦ: да Цитирований в РИНЦ: 0 Входит в ядро РИНЦ: нет Цитирований из ядра РИНЦ: 0 Рецензии: нет данных Процентиль журнала в рейтинге SI: 65 ТЕМАТИЧЕСКИЕ НАПРАВЛЕНИЯ: Рубрика OECD: Clinical medicine Рубрика ASJC: нет Рубрика ГРНТИ: Медицина и здравоохранение / Клиническая медицина / Акушерство и гинекология Специальность ВАК: нет Приоритет СНТР РФ: нет АЛЬТМЕТРИКИ: Просмотров: 59 (18) Загрузок: 12 (8) Включено в подборки: 46 Всего оценок: 0 Средняя оценка: Всего отзывов: 0 ОПИСАНИЕ НА АНГЛИЙСКОМ ЯЗЫКЕ: MODERN IDEAS ON THE ROLE OF MACROPHAGES AND NEUTROPHILS IN THE DEVELOPMENT OF ENDOMETRIOSIS MARTYNOVA L.1, CHAULIN A.*2,3, VANKOV V.2, GRIGORYEVA YU.2 1 Samara City Hospital no.6, Samara, Russia 2Samara State Medical University, Samara, Russia 3Samara Regional Cardiology Dispensary Endometriosis is one of the most common gynecological diseases. Methods of diagnosis and treatment of endometriosis are imperfect, which is probably due to insufficient knowledge of the pathogenesis of this disease. Recently, research efforts have focused on the study of immunoinflammatory mechanisms in the development and progression of endometriosis. Understanding the pathogenetic mechanisms of endometriosis is important for the discovery of new laboratory biomarkers for early diagnosis and new targets for therapeutic effects. This article summarizes information on the role of some of the main cells of the immune system (macrophages and neutrophils) in the pathogenesis of endometriosis.

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