Modern Ideas on the Role of Macrophages and Neutrophils in the Development of Endometriosis

L.I. Martynova, Aleksey M. Chaulin, Vladimir Vankov, Julia Grigoryeva
In: Bulletin of Science and Practice · 2023 · pp. 159–174 · doi:10.33619/2414-2948/94/19 · W4386735094
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review summarizes current knowledge regarding the involvement of macrophages and neutrophils in the pathogenesis and progression of endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This review article examines current ideas about the role of immune-inflammatory mechanisms in the development and progression of endometriosis, focusing specifically on macrophages and neutrophils. The authors describe why improved understanding of endometriosis pathogenesis is needed, and frame their synthesis as supporting future discovery of laboratory biomarkers for early diagnosis and therapeutic targets. A key limitation explicitly noted is that diagnosis and treatment remain imperfect, attributed to insufficient knowledge of the disease pathogenesis, which motivates the review rather than providing new experimental results. This paper is centrally about endometriosis — it summarizes macrophage and neutrophil roles in endometriosis pathogenesis.

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Abstract

Endometriosis is one of the most common gynecological diseases. Methods of diagnosis and treatment of endometriosis are imperfect, which is probably due to insufficient knowledge of the pathogenesis of this disease. Recently, research efforts have focused on the study of immunoinflammatory mechanisms in the development and progression of endometriosis. Understanding the pathogenetic mechanisms of endometriosis is important for the discovery of new laboratory biomarkers for early diagnosis and new targets for therapeutic effects. This article summarizes information on the role of some of the main cells of the immune system (macrophages and neutrophils) in the pathogenesis of endometriosis.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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last seen: 2026-06-10T17:14:06.276822+00:00
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