Neutrophil depletion reduces endometriotic lesion formation in mice

Masashi Takamura, Kaori Koga, Gentaro Izumi, Yoko Urata, Miwako Nagai, Akiko Hasegawa, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Wada-Hiraike, Osamu Wada‐Hiraike, Tomoyuki Fujii, Yutaka Osuga
American journal of reproductive immunology (New York, N.Y. : 1989) · 2016 · vol. 76(3) , pp. 193–198 · doi:10.1111/aji.12540 · PMID:27432477 · W2498683695
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This study found that depleting neutrophils in mice during the early stage of endometrial fragment transplantation significantly reduced the number of endometriotic lesions formed.

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Abstract

PROBLEM: Neutrophils are known to be accumulated in endometriosis; however, direct evidence of the impact of neutrophils in the development of endometriosis was lacking. To clarify the importance of neutrophils, we examined the effect of neutrophil depletion on the development of endometriosis. METHOD OF STUDY: Ovariectomized, estradiol-replaced, 8-week-old, female BALB/c mice were injected with endometrial fragments (Day 0). Neutrophils were depleted by anti-Gr-1 antibody, either in the early stage (from Day 1 to Day 3, group E) or late stage (from Day 8 to Day 12, group L). Control mice (group C) did not receive antibodies. On Day 14, mice were killed and the number and weight of endometriotic lesions were counted and weighed. RESULTS: The number of endometriotic lesions was significantly less in group E in comparison with Group C and Group L. Weight per lesion did not differ between groups. CONCLUSION: Neutrophils are essential for the initial formation of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Neutrophils Animals Antibodies Antibodies Endometriosis Endometriosis Female Mice Mice, Inbred BALB C Neutrophils Neutrophils

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