Trophic and immunomodulatory effects of adipose tissue derived stem cells in a preclinical murine model of endometriosis

Toyofumi Hirakawa, Fusanori Yotsumoto, Naoto Shirasu, Chihiro Kiyoshima, Daichi Urushiyama, Kenichi Yoshikawa, Kohei Miyata, Masamitsu Kurakazu, Kaori Azuma Koga, Mikiko Aoki, Kazuki Nabeshima, Kaori S Koga, Kaori Koga, Yutaka Osuga, Hiroaki Komatsu, Fuminori Taniguchi, Tasuku Harada, Shin'ichiro Yasunaga, Shin’ichiro Yasunaga, Shingo Miyamoto
Scientific reports · 2022 · vol. 12(1) , pp. 8031 · doi:10.1038/s41598-022-11891-5 · PMID:35577867 · PMC9110373 · W4280505872
article OA: gold CC0 ⤵ 6 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Adipose-derived stem cells with stemness potential suppressed growth and fibrosis in a murine endometriosis model by reducing pro-inflammatory and pro-fibrotic cytokines.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated whether intravenous administration of adipose tissue-derived stem cells (ASCs) could alter established endometriosis-like lesions in a preclinical murine model, and compared early-passage ASCs with stemness potential to late-passage ASCs with reduced stemness. Labeled ASCs integrated into lesions, and early-passage ASCs significantly suppressed lesion weight, number, and surface area, along with reductions in stromal fibrosis and in endometriotic epithelial proliferation (via Ki67) plus downregulation of pro-inflammatory and pro-fibrotic cytokine expression; late-passage ASCs did not produce significant attenuation. The authors also report that serial passaging markedly decreased MSC marker/stemness potential, which served as a caveat when interpreting efficacy differences. This paper is centrally about endometriosis — it tests trophic and immunomodulatory effects of early vs late adipose-derived stem cells in a mouse model of endometriosis-like lesions.

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Abstract

Endometriosis, which exhibits enigmatic pathological features such as stromal fibrosis and proliferation of ectopic epithelial cells, is known as a refractory disease. Mesenchymal stem cells modulate the fibrosis in stromal tissues through their trophic and immunomodulatory properties. To investigate the potential of stem cells in treating endometriosis, we examined the secondary morphology and molecular alterations in endometriosis-like lesions after the administration of adipose tissue-derived stem cells (ASCs) to an experimental murine model of endometriosis. The infused ASCs were found integrated in the endometriosis-like lesions. Accompanied by the suppression of stromal fibrosis and proliferation of endometriotic epithelial cells, the infusion of ASCs with stemness potential (early passage of ASCs) suppressed the growth of endometriosis-like lesions and inhibited the expression of pro-inflammatory and pro-fibrotic cytokines, whereas no significant attenuation of endometriosis-like lesions occurred after the infusion of ASCs without stemness potential (late passage of ASCs). Accordingly, the trophic and immunomodulatory properties of ASCs may regulate fibrosis in endometriosis-like lesions, suggesting that regenerative medicine could be recognized as an innovative treatment for patients with endometriosis through the accumulation of evidence of preclinical efficacy.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Adipose Tissue Adipose Tissue Adipose Tissue Adipose Tissue Adipose Tissue Adipose Tissue Adipose Tissue Adipose Tissue Adipose Tissue Animals

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