Local and systemic levels of cytokines and danger signals in endometriosis-affected women

Agnes Jaeger-Lansky, Jaeger-Lansky A, Klara Schmidthaler, Lorenz Kuessel, Manuela Gstöttner, Gstöttner M, Petra Waidhofer-Söllner, Petra Waidhofer‐Söllner, Gerhard J. Zlabinger, René Wenzl, Wenzl R, Thomas Eiwegger
Journal of Reproductive Immunology · 2018 · vol. 130 , pp. 7–10 · doi:10.1016/j.jri.2018.07.006 · PMID:30099220 · W2884033905
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This study investigated local and systemic levels of cytokines and danger signals in women with endometriosis, analyzing their correlations with disease severity and symptoms.

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Abstract

Endometriosis is a prevalent gynaecological disorder with a still unclear pathogenesis. So far inflammatory mechanisms are associated with disease progression and critical reviews have discussed the so-called 'danger theory' related to endometriosis. Hence, we performed immunoassays to evaluate whether local inflammation is linked to the severity of the disease. In addition, we investigated the role of recently described cytokines IL-33, IL-32α and the 'alarmin' high mobility group box 1 (HMGB1). We confirmed a dysfunctional immune response in the local environment of women suffering from endometriosis. However, we found no direct evidence for a significant up-regulation of danger signals in endometriosis, irrespective of the severity of the disease.

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Condition tags

endometriosis

MeSH descriptors

Alarmins Endometriosis HMGB1 Protein Interleukin-33 Adult Alarmins Alarmins Alarmins Biomarkers Biomarkers Biomarkers Endometriosis Endometriosis Endometriosis Endometriosis Female HMGB1 Protein HMGB1 Protein HMGB1 Protein Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (20)

Cited by (38)

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