Angiogenic activity and IL‐8 concentrations in peritoneal fluid and sera in endometriosis

Ewa Barcz, E Barcz, E Skopinska Rózewska, Paweł Kamiński, P Kaminski, Urszula Demkow, U Demkow, K Bobrowska, L Marianowski
International Journal of Gynecology & Obstetrics · 2002 · vol. 79(3) , pp. 229–235 · doi:10.1016/s0020-7292(02)00308-9 · PMID:12445988 · W2120612645
article OA: closed CC0 ⤵ 31 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study found that peritoneal fluid and sera from endometriosis patients exhibit higher angiogenic activity and interleukin-8 concentrations, correlating with lesion neovascularization.

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Abstract

OBJECTIVES: During menstruation endometrial fragments are transported into the peritoneal cavity where they form endometriotic lesions. Angiogenesis is proposed as one of the mechanisms in endometriosis pathogenesis. The aim of the study was to determine the angiogenic activity and interleukin 8 concentrations in peritoneal fluid and sera in endometriosis. METHODS: Angiogenesis was determined in cutaneous assay in Balb/c mice; IL-8 concentrations were measured by ELISA test in sera and peritoneal fluid of 32 control and 56 endometriosis patients. Wilcoxon and Mann-Whitney tests and Spearman rank correlations were used in statistical analysis. RESULTS: Peritoneal fluid and sera from the examined group had higher angiogenic activity and interleukin 8 concentrations. There was correlation found between AFS and neovascularization induced by sera and PF of patients with peritoneal lesions. CONCLUSIONS: Angiogenesis plays an important role in pathogenesis of endometriosis. Although IL-8 takes part in neovascularization, there are other factors modulating angiogenesis in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-8 Neovascularization, Physiologic Animals Ascitic Fluid Endometriosis Endometriosis Female Humans Interleukin-8 Interleukin-8 Mice Mice, Inbred BALB C

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (21)

Cited by (31)

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