Progress on macrophage's proinflammatory products as markers of acute endometriosis

Alicja Ziętek, Konrad Futyma, Łukasz Nowakowski, Marek Gogacz, Tomasz Rechberger
In: Journal of Acute Disease · 2015 · vol. 4(3) , pp. 169–172 · doi:10.1016/j.joad.2015.04.001 · W1205832485
article OA: diamond CC0 ⤵ 7 in-corpus citations
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Activated macrophages in endometriosis patients secrete elevated proinflammatory cytokines, contributing to inflammation and lesion development, suggesting potential as disease markers and therapeutic targets.

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Abstract

To provide the review of the macrophage activity products as pathophysiological markers of endometriosis by literature survey (PubMed, Cochrane). Immunoreactive cells and several of their synthesis products concentrations are elevated in the serum and peritoneal fluid in patients with endometriosis. The enhanced reactive proteins contributed to local inflammation and aggregation of endometriotic lesions. Immune response and immune surveillance of tissue play an important role in pathogenesis of endometriosis. Activated macrophages in peritoneal environment secrete immunoreactive cytokines which are responsible for inflammatory cascade of reactions. The immunoreactive cytokines should be a target not only as a disease marker but also as a part of therapeutic protocol.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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