Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis

D P Braun, Braun DP, Donald P. Braun, Howard M. Gebel, Gebel H, H Gebel, R House, House R, Robert V. House, N Rana, Nasir Rana, Rana N, N P Dmowski, Dmowski NP, W. Paul Dmowski
Fertility and sterility · 1996 · vol. 65(6) , pp. 1125–1129 · doi:10.1016/s0015-0282(16)58325-3 · PMID:8641484 · W2242098259
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Peripheral blood monocytes from women with endometriosis spontaneously produce higher levels of IL-6, TNF-alpha, and IL-1 beta, and show an enhanced response to LPS stimulation.

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Abstract

ObjectiveTo investigate the capacity of peripheral blood monocytes (PBM) from women with endometriosis to secrete tumor necrosis factor-alpha (TNF-alpha), interleukin (IL) IL-6, IL-8, and IL-10.DesignPeripheral blood monocytes were cultured in the presence and absence of lipopolysaccharide for 24 hours before assessment of cytokines in supernatants by enzyme immunoassay.SettingInstitute for the Study and Treatment of Endometriosis and university-based research laboratories.Patients and participantsFertile controls, n - 10; women with endometriosis, n = 20.InterventionsNone.ResultsBasal synthesis of TNF-alpha, IL-6, and IL-8 and the lipopolysaccharide-stimulated synthesis of TNF-alpha by PBM from women with endometriosis was significantly greater in comparison to that of fertile controls. Endometriosis had no effect on the basal or stimulated synthesis of IL-10.ConclusionsThese data show that endometriosis is associated with increased basal and stimulated synthesis and secretion of several different cytokines by PBM. Each of the cytokines found to be affected has the capacity to play a role in the symptomatology or pathogenesis of the disease.

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Condition tags

endometriosis

MeSH descriptors

Cytokines Endometriosis Monocytes Cytokines Endometriosis Female Humans Interleukin-10 Interleukin-10 Interleukin-6 Interleukin-6 Interleukin-8 Interleukin-8 Lipopolysaccharides Lipopolysaccharides Monocytes Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha

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