The role of serum IL-6 changes in evaluation of endometriosis

Tharwa H. Hassan AL-Tai, Hayfaa S. AL-Hadithi, Hind S. Abdulsalam
In: Journal of the Faculty of Medicine Baghdad · 2013 · vol. 55(2) , pp. 158–161 · doi:10.32007/jfacmedbagdad.552646 · W3120737494
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This study investigated serum IL-6 levels in women with endometriosis, finding significantly decreased levels in stage IV disease and following treatment, suggesting potential as a specific but low-sensitivity early detection marker.

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This study evaluated whether serum interleukin-6 (IL-6) levels correlate with the severity of endometriosis in 51 women with endometriosis (20 newly diagnosed and 31 treated with danazol or zoladex) and 33 healthy controls, measuring IL-6 by ELISA in samples collected from November 2011 to January 2012. IL-6 levels were generally higher in endometriosis, but the results reported that IL-6 serum levels were significantly decreased in stage IV disease and were also affected by danazol/zoladex treatment, remaining low even among treated patients. The authors concluded that serum IL-6 testing was highly specific but had low sensitivity, and they presented it as a potential early detection marker. This paper is centrally about endometriosis — it assesses how serum IL-6 relates to endometriosis severity and diagnostic performance.

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Abstract

Background:- Endometriosis is a common chronic gynecological disorder characterized by the presence and proliferation of functional endometrial gland and stroma outside the uterine cavity, affecting approximately 10% of reproductive age women. Il-6 level increased in the patient with endometriosis.Objective:- Evaluate the correlation of IL-6 levels with the degree of severity of endometriosisPatients and methods:- In this study, 84 samples 51women with endometriosis (20 newly diagnosed and 31 treated cases) and 33 of healthy control group, were collected starting from November 2011 to end of January 2012, to investigate the IL-6 serum level by using ELISA kit.Results :- Endometriosis patients mainly presented at the age between (28-37). IL-6 serum levels were significantly decrease in those with stage IV endometriosis. Also appear to be significantly affected by the use of danazol or zoladex treatment of endometriosis and remain low even in treated patients. Serum IL-6 test was highly specific but with low sensitivity.Conclusion:-Serum IL-6 concentration seem to be the highly specific test that can be used as an early detection marker for endometriosis.
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The role of serum IL-6 changes in evaluation of endometriosis DOI: https://doi.org/10.32007/jfacmedbagdad.552646Keywords: Endometriosis, IL-6.Abstract Background:- Endometriosis is a common chronic gynecological disorder characterized by the presence and proliferation of functional endometrial gland and stroma outside the uterine cavity, affecting approximately 10% of reproductive age women. Il-6 level increased in the patient with endometriosis. Objective:- Evaluate the correlation of IL-6 levels with the degree of severity of endometriosis Patients and methods:- In this study, 84 samples 51women with endometriosis (20 newly diagnosed and 31 treated cases) and 33 of healthy control group, were collected starting from November 2011 to end of January 2012, to investigate the IL-6 serum level by using ELISA kit. Results :- Endometriosis patients mainly presented at the age between (28-37). IL-6 serum levels were significantly decrease in those with stage IV endometriosis. Also appear to be significantly affected by the use of danazol or zoladex treatment of endometriosis and remain low even in treated patients. Serum IL-6 test was highly specific but with low sensitivity. Conclusion:-Serum IL-6 concentration seem to be the highly specific test that can be used as an early detection marker for endometriosis.

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endometriosis

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